Horev Amir, Freud Tamar, Manor Iris, Cohen Arnon D, Zvulunov Alex
Amir Horev, MD, Pediatric dermatology service, Soroka University Medical Center, PO Box 151, Beer-Sheva, Israel;
Acta Dermatovenerol Croat. 2017 Oct;25(3):210-214.
Atopic dermatitis (AD) is a common, chronic, inflammatory, pruritic skin disorder that affects up to 20% of the children in Western countries. Attention-Deficit/Hyperactivity disorder (ADHD) has been reported to be more frequent in children with AD. The purpose of this study was to explore the risk for ADHD in our population of patients with AD. A population-based case-control study, using the medical database of Clalit Health Services (CHS), the largest healthcare provider organization in Israel. The study included 840 patients with AD between the age of 0-18 years and 900 age and gender frequency-matched patients without AD. The proportion of ADHD in patients with AD was 7.1% as compared to 4.1% in controls. ADHD was more frequent in boys with AD (9.6% vs. 5.2%, odds ratio (OR) 1.9, 95% confidence interval (CI) 1.1-3.2) but not in girls with AD (4.6% vs. 2.9% OR 1.5). In multivariate analyses, AD was associated with ADHD (OR 2.1, 95% CI 1.3-3.4). The current study demonstrated an association between AD and ADHD. This report and earlier observations emphasize the need for detection and treatment of ADHD in atopic patients.
特应性皮炎（AD）是一种常见的慢性炎症性瘙痒性皮肤病，在西方国家影响着高达20%的儿童。据报道，注意缺陷多动障碍（ADHD）在AD患儿中更为常见。本研究的目的是探讨我们的AD患者群体中患ADHD的风险。一项基于人群的病例对照研究，使用以色列最大的医疗服务提供商组织克拉利特健康服务（CHS）的医疗数据库。该研究纳入了840名0至18岁的AD患者以及900名年龄和性别频率匹配的非AD患者。AD患者中ADHD的比例为7.1%，而对照组为4.1%。AD男性患儿中ADHD更为常见（9.6%对5.2%，优势比（OR）为1.9，95%置信区间（CI）为1.1 - 3.2），但AD女性患儿中并非如此（4.6%对2.9%，OR为1.5）。在多变量分析中，AD与ADHD相关（OR为2.1，95%CI为1.3 - 3.4）。当前研究证明了AD与ADHD之间存在关联。本报告及早期观察结果强调了在特应性患者中检测和治疗ADHD的必要性。
