Division of Cardiothoracic Surgery, Department of Surgery, Columbia University College of Physicians and Surgeons/NewYork-Presbyterian Hospital, New York, NY, USA.
Department of Surgery, Columbia University College of Physicians and Surgeons/NewYork-Presbyterian Hospital, New York, NY, USA.
Eur J Cardiothorac Surg. 2018 Apr 1;53(4):793-798. doi: 10.1093/ejcts/ezx452.
Extracorporeal membrane oxygenation (ECMO) transport has not been described in morbidly obese patients, a population that can pose significant challenges in obtaining vascular access, indexed flows and transport logistics. We sought to study the feasibility and safety of transporting obese and morbidly obese patients during extracorporeal support.
We conducted a retrospective review of all patients transported to our institution while receiving ECMO from September 2008 to September 2016. Survival to decannulation and survival to discharge were the primary outcomes. Obesity and morbid obesity were defined as a body mass index of greater than 30 kg/m2 and greater than 40 kg/m2, respectively.
From 2008 to 2016, 222 patients were transported to our institution while receiving ECMO. Among these included patients, 131 were non-obese (interquartile range 22-27 kg/m2), 63 were obese (interquartile range 31-35 kg/m2) and 28 were morbidly obese (interquartile range 41-49 kg/m2), with 6 patients having a body mass index greater than 50 kg/m2 (range 52.3-79 kg/m2). Pre-ECMO arterial blood gases, disease severity indices, cannulation strategies and transport distances were similar between these 3 groups. There was no mortality of patients during transport, and survival to discharge was 66% (n = 87) in non-obese patients, 56% (n = 35) in obese patients and 82% (n = 23) in morbidly obese patients (P = 0.042). On multivariable logistic regression analysis, body mass index was not a predictor of in-hospital mortality (odds ratio 0.99, 95% confidence interval 0.95-1.03; P = 0.517).
Transport of morbidly obese patients receiving ECMO may be performed safely and with excellent results in the setting of a dedicated ECMO transport programme with well-established management protocols.
体外膜肺氧合(ECMO)转运在病态肥胖患者中尚未得到描述,这类患者在获得血管通路、指数流量和转运物流方面可能会面临重大挑战。我们旨在研究在体外支持期间转运肥胖和病态肥胖患者的可行性和安全性。
我们对 2008 年 9 月至 2016 年 9 月期间在我院接受 ECMO 治疗的所有接受转运的患者进行了回顾性研究。脱机和出院存活率是主要结果。肥胖和病态肥胖分别定义为体重指数大于 30kg/m2 和大于 40kg/m2。
2008 年至 2016 年,我院共转运 222 例接受 ECMO 治疗的患者。其中 131 例为非肥胖患者(四分位距 22-27kg/m2),63 例为肥胖患者(四分位距 31-35kg/m2),28 例为病态肥胖患者(四分位距 41-49kg/m2),其中 6 例患者的体重指数大于 50kg/m2(范围 52.3-79kg/m2)。这 3 组患者的 ECMO 前动脉血气、疾病严重程度指数、置管策略和转运距离相似。在转运过程中,没有患者死亡,非肥胖患者的出院存活率为 66%(n=87),肥胖患者为 56%(n=35),病态肥胖患者为 82%(n=23)(P=0.042)。多变量逻辑回归分析显示,体重指数不是院内死亡率的预测因素(比值比 0.99,95%置信区间 0.95-1.03;P=0.517)。
在建立了完善的管理方案的专门 ECMO 转运计划下,对接受 ECMO 治疗的病态肥胖患者进行转运是安全的,并且可以取得良好的效果。