Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
OneMatch Stem Cell and Marrow Network, Ottawa, Ontario, Canada.
Biol Blood Marrow Transplant. 2018 Apr;24(4):861-865. doi: 10.1016/j.bbmt.2017.11.032. Epub 2017 Dec 15.
Zika virus has emerged as a potential threat to the Canadian blood supply system. Stem cell donors within Canadian Blood Services' Cord Blood Bank (CBB) and OneMatch Stem Cell and Marrow Network (OM) now undergo screening measures designed to reduce the risk of Zika virus transmission. The impact these screening measures have on cord blood and unrelated adult stem cell donations is currently unknown. Among 146 donor workups initiated by OM between July 2016 and May 2017, 102 were completed and 44 workups were canceled. There were 17 potential donors (11.6%) with a risk of Zika virus exposure identified by the donor questionnaire (13 completed, 4 canceled workups). None of the workups involved a donor diagnosed with confirmed Zika virus within the past 6 months. Only 1 of the 44 canceled workups (and only 1 of 4 cases with a risk of Zika transmission) was canceled because of the risk of Zika transmission, and a backup donor was selected. Canadian Blood Services' CBB identified 25 of 875 cord blood units (2.9%) from women who donated their infants' cord blood and underwent screening that otherwise met the initial cell number thresholds for banking and had at least 1 risk factor for exposure to Zika virus. No women were diagnosed with Zika virus at any point of their pregnancy. All 25 units were discarded. Unrelated donors at OM have a higher incidence of a risk of exposure to Zika virus compared with cord blood donors. Only rarely did transplant centers cancel donor workups due to potential Zika virus exposure. The impact of screening for Zika virus exposure risk on cord blood banking was minor. Continued vigilance and surveillance is recommended.
寨卡病毒已成为加拿大血液供应系统的潜在威胁。加拿大血液服务中心脐带血库（CBB）和 OneMatch 干细胞和骨髓网络（OM）中的干细胞供者现在接受旨在降低寨卡病毒传播风险的筛选措施。这些筛选措施对脐带血和非亲缘成人干细胞捐献的影响目前尚不清楚。在 OM 于 2016 年 7 月至 2017 年 5 月期间启动的 146 项供者检查中，有 102 项完成，44 项被取消。通过供者问卷调查发现有 17 名潜在供者（11.6%）有寨卡病毒暴露的风险（完成 13 项，取消 4 项检查）。在这 146 项检查中，没有一项涉及在过去 6 个月内被诊断患有确诊寨卡病毒的供者。在 44 项取消的检查中，只有 1 项（仅有 4 例有寨卡病毒传播风险的检查）因寨卡病毒传播风险而被取消，并且选择了备用供者。加拿大血液服务中心的 CBB 从捐赠婴儿脐带血并接受筛查的 875 名妇女中发现了 25 个脐带血单位（2.9%），这些妇女的筛查符合最初的细胞数量存入银行的标准，并且至少有 1 个感染寨卡病毒的风险因素。在妊娠的任何阶段都没有妇女被诊断患有寨卡病毒。所有 25 个单位均被丢弃。与脐带血供者相比，OM 的非亲缘供者有更高的寨卡病毒暴露风险。只有极少数移植中心因潜在的寨卡病毒暴露而取消供者检查。筛查寨卡病毒暴露风险对脐带血银行的影响很小。建议继续保持警惕和监测。
