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输尿管镜检查中冲洗与篮取术——哪种技术更有效?EDG 研究联盟的一项前瞻性多中心试验。

Dusting versus Basketing during Ureteroscopy-Which Technique is More Efficacious? A Prospective Multicenter Trial from the EDGE Research Consortium.

机构信息

Mayo Clinic, Phoenix, Arizona.

Columbia University, New York, New York.

出版信息

J Urol. 2018 May;199(5):1272-1276. doi: 10.1016/j.juro.2017.11.126. Epub 2017 Dec 16.

DOI:10.1016/j.juro.2017.11.126
PMID:29253579
Abstract

PURPOSE

There is scant evidence in the literature to support dusting vs active basket extraction during ureteroscopy for kidney stones. We prospectively evaluated and followed patients to determine which modality produced a higher stone-free rate with the fewest complications.

MATERIALS AND METHODS

Members of the Endourologic Disease Group for Excellence research consortium prospectively enrolled patients with a renal stone burden ranging from 5 to 20 mm in this study. A holmium laser was used and all patients were stented postoperatively. Ureteral access sheaths were used in 100% of basketing cases while sheaths were optional when dusting. The primary study outcome was the stone-free rate at 6 weeks as determined by x-ray and ultrasound.

RESULTS

A total of 84 and 75 patients were enrolled in the basketing and dusting arms, respectively. Stones in the dusting group were significantly larger (mean ± SD stone area 96.1 ± 65.3 vs 63.3 ± 46.0 mm, p <0.001). The stone-free rate was significantly higher in the basketing group on univariate analysis (74.3% vs 58.2%, p = 0.04) but not on multivariate analysis (1.9 OR, 95% CI 0.9-4.3, p = 0.11). In patients who underwent a basketing procedure operative time was 37.7 minutes longer than in those treated with a dusting procedure (95% CI 23.8-51.7, p <0.001). There was no statistically significant difference in complication rates, hospital readmissions or additional procedures between the groups.

CONCLUSIONS

The stone-free rate was higher for active basket retrieval of fragments at short-term followup on univariate analysis but not on multivariate analysis. There was no difference in postoperative complications or procedures. The 2 techniques should be in the armamentarium of the urologist.

摘要

目的

在输尿管镜取石术中,关于滑石粉与主动篮取石的文献证据很少。我们前瞻性评估并随访患者,以确定哪种方式产生更高的无石率,同时并发症最少。

材料与方法

卓越泌尿内科学组研究联盟的成员前瞻性地招募了这项研究中肾结石负荷范围在 5 至 20mm 的患者。所有患者均使用钬激光治疗,并在术后进行支架置入。在篮取术中 100%使用输尿管通道鞘,而在滑石粉术时则使用鞘为可选。主要研究结果是 X 射线和超声检查确定的 6 周时的无石率。

结果

共有 84 例和 75 例患者分别入组到篮取术组和滑石粉术组。滑石粉术组的结石明显更大(平均±标准差结石面积 96.1±65.3 比 63.3±46.0mm,p<0.001)。单因素分析显示,篮取术组的无石率显著更高(74.3%比 58.2%,p=0.04),但多因素分析无显著差异(1.9OR,95%CI0.9-4.3,p=0.11)。在接受篮取术的患者中,手术时间比接受滑石粉术的患者长 37.7 分钟(95%CI23.8-51.7,p<0.001)。两组之间的并发症发生率、住院再入院率或其他治疗方法无统计学差异。

结论

在短期随访的单因素分析中,主动篮取结石碎片的无石率更高,但多因素分析无显著差异。术后并发症或治疗方法无差异。这两种技术都应该是泌尿科医生的工具。

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