Kopp M S, Arató M, Magyar I, Buza K
Department of Psychiatry, Semmelweis Medical University, Budapest, Hungary.
Int J Psychophysiol. 1989 Mar;7(1):77-83. doi: 10.1016/0167-8760(89)90033-0.
Twenty nine patients with panic disorder or agoraphobia with panic attacks were studied. The relationship between pre- and postdexamethasone serum cortisol level and electrodermal lability as reflected in electrodermal habituation rate and resting non-specific electrodermal activity was investigated. The frequency of non-suppression of cortisol following dexamethasone (DST non-suppressors) (at 5 micrograms/dl cut-off level) was 29.6% for the total group of patients. The basal plasma cortisol concentration showed positive correlation with the electrodermal habituation rate. The basal plasma cortisol level of slow habituator panic patients was significantly higher compared to rapid habituator patients, and it was above the normal range. On the contrary in rapid habituator panic patients the pre- and postdexamethasone cortisol difference was significantly less than in slow habituator patients, due to the normal basal plasma cortisol level and the relatively reduced rate of feedback suppression of cortisol following dexamethasone. Of the rapid habituator panic patients, 50% were non-suppressors following dexamethasone (at 5 micrograms/dl cut-off level). The above results might reflect two relatively different patterns of hypothalamic-pituitary-adrenal dysregulation in connection with two extremes of electrodermal habituation rate in panic patients.
对29例惊恐障碍或伴有惊恐发作的广场恐惧症患者进行了研究。研究了地塞米松前后血清皮质醇水平与皮肤电不稳定性之间的关系，皮肤电不稳定性通过皮肤电习惯化率和静息非特异性皮肤电活动来反映。在地塞米松治疗后皮质醇未被抑制的频率（DST未抑制者）（以5微克/分升为临界值）在患者总组中为29.6%。基础血浆皮质醇浓度与皮肤电习惯化率呈正相关。与快速习惯化的惊恐患者相比，缓慢习惯化的惊恐患者的基础血浆皮质醇水平显著更高，且高于正常范围。相反，在快速习惯化的惊恐患者中，地塞米松前后的皮质醇差异显著小于缓慢习惯化的患者，这是由于基础血浆皮质醇水平正常以及地塞米松后皮质醇的反馈抑制率相对降低。在快速习惯化的惊恐患者中，50%在地塞米松治疗后（以5微克/分升为临界值）为未抑制者。上述结果可能反映了惊恐患者下丘脑-垂体-肾上腺调节异常的两种相对不同模式，这与皮肤电习惯化率的两个极端情况有关。
