无糖尿病的女性在妊娠早期的血糖值与后代先天性心脏病的发病风险相关。
First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring.
机构信息
Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA; Children's Hospital, University of Helsinki, Helsinki, Finland.
Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA.
出版信息
J Pediatr. 2018 Apr;195:275-278. doi: 10.1016/j.jpeds.2017.10.046. Epub 2017 Dec 15.
Abstract
In a retrospective study of 19 171 mother-child dyads, elevated random plasma glucose values during early pregnancy were directly correlated with increased risk for congenital heart disease in offspring. Plasma glucose levels proximal to the period of cardiac development may represent a modifiable risk factor for congenital heart disease in expectant mothers without diabetes.
摘要
在一项对 19171 对母婴对子的回顾性研究中，妊娠早期随机血浆葡萄糖值升高与后代先天性心脏病风险增加直接相关。心脏发育期间接近的血浆葡萄糖水平可能代表了无糖尿病孕妇先天性心脏病的一个可改变的危险因素。
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