Regional Blood Center of Ribeirão Preto, Ribeirão Preto School of Medicine, University of São Paulo, Brazil.
Department of Paeditarics, Ribeião Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Pathol Res Pract. 2018 Feb;214(2):213-216. doi: 10.1016/j.prp.2017.11.020. Epub 2017 Dec 2.
Dysregulated mitotic kinases have frequently been associated with cancer. Changes in their expression might result from diverse mechanisms including avoidance of the tight regulation exerted by miRNAs. Herein we show that miR-10b* is downregulated in osteosarcoma samples and demonstrate its correlation with PLK1, PLK4, BUB1, and BUBR1, which are strongly intercorrelated. The selection of miRNAs that coordinately target and regulate multiple members of cancer-related pathways are particularly advantageous to tumors. Thus, even though no associations with clinical parameters were found, our data place miR-10b* as a tumor suppressor that might contribute to guarantee genomic stability, deserving further functional confirmation.
失调的有丝分裂激酶经常与癌症有关。它们的表达变化可能来自多种机制，包括逃避 miRNA 施加的严格调控。在此，我们表明 miR-10b在骨肉瘤样本中下调，并证明其与 PLK1、PLK4、BUB1 和 BUBR1 相关，这些基因之间存在强烈的相关性。选择协调靶向和调节多个癌症相关途径成员的 miRNA 对肿瘤特别有利。因此，尽管我们没有发现与临床参数的关联，但我们的数据将 miR-10b 作为一种肿瘤抑制因子，可能有助于保证基因组的稳定性，值得进一步的功能验证。
