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miR-548d-3p通过下调……抑制骨肉瘤。

miR-548d-3p inhibits osteosarcoma by downregulating .

作者信息

Chen Jianhua, Yan Chongnan, Yu Honghao, Zhen Shihan, Yuan Quan

机构信息

Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110001, People's Republic of China.

出版信息

Aging (Albany NY). 2019 Jul 21;11(14):5058-5069. doi: 10.18632/aging.102097.

DOI:10.18632/aging.102097
PMID:31327761
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6682526/
Abstract

MicroRNAs (miRNAs) are known to be associated with certain cancers, including osteosarcoma. We examined osteosarcoma tissues and cell lines, and found that most expressed lower levels of miR-548d-3p than adjacent tissues and normal cell lines. was identified as a potential target gene of miR-548d-3p. In osteosarcoma cells, miR-548d-3p exerted tumor-suppressive effects by downregulating . Functional assays revealed that miR-548d-3p mimics dramatically reduced cell growth and migration . These results suggest that miR-548d-3p mimics could be applied for osteosarcoma treatment.

摘要

已知微小RNA（miRNA）与某些癌症相关，包括骨肉瘤。我们检测了骨肉瘤组织和细胞系，发现大多数骨肉瘤组织和细胞系中miR-548d-3p的表达水平低于相邻组织和正常细胞系。 被鉴定为miR-548d-3p的潜在靶基因。在骨肉瘤细胞中，miR-548d-3p通过下调 发挥肿瘤抑制作用。功能分析表明，miR-548d-3p模拟物显著降低细胞生长和迁移 。这些结果表明，miR-548d-3p模拟物可用于骨肉瘤治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b511/6682526/1764f1c3029d/aging-11-102097-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b511/6682526/4d1dc12939e1/aging-11-102097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b511/6682526/042e9816e099/aging-11-102097-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b511/6682526/829587e82057/aging-11-102097-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b511/6682526/33e5049e1800/aging-11-102097-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b511/6682526/1764f1c3029d/aging-11-102097-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b511/6682526/4d1dc12939e1/aging-11-102097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b511/6682526/042e9816e099/aging-11-102097-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b511/6682526/829587e82057/aging-11-102097-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b511/6682526/33e5049e1800/aging-11-102097-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b511/6682526/1764f1c3029d/aging-11-102097-g005.jpg

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