Gardner I A, Hird D W, Franti C E, Glenn J S
Department of Epidemiology and Preventive Medicine, School of Veterinary Medicine, University of California, Davis 95616.
J Am Vet Med Assoc. 1989 Mar 1;194(5):659-63.
Prophylactic efficacy of 100 mg of long-acting oxytetracycline (OTC) given IM to neonatal pigs within 12 hours of birth was evaluated in a swine herd. The herd had a history of increased neonatal mortality, diarrhea, foot abscess, and arthritis in nursing pigs. Two trials were conducted in which liters and individual pigs were the treatment groups of interest. In both trials, OTC treatment failed to reduce mortality, diarrhea, or arthritis or the need for subsequent antimicrobial therapy (P greater than 0.05). Preweaning weight gains were not increased (P greater than 0.05) in treated pigs. However, in the individual pig trial, foot abscess rates were significantly (P = 0.01) lower in treated pigs (3.7%) than in nontreated pigs (8%). Aerobic bacteria isolated from pigs with diarrhea, arthritis, or foot abscess had minimum inhibitory concentrations for OTC greater than or equal to 64 micrograms/ml or were classed as resistant on the basis of disk-diffusion tests.
在一个猪群中评估了在新生仔猪出生后12小时内肌肉注射100毫克长效土霉素（OTC）的预防效果。该猪群有新生仔猪死亡率增加、腹泻、足部脓肿和哺乳仔猪关节炎的病史。进行了两项试验，其中窝和个体仔猪是感兴趣的治疗组。在两项试验中，OTC治疗均未能降低死亡率、腹泻或关节炎，也未减少后续抗菌治疗的需求（P大于0.05）。治疗仔猪的断奶前体重增加未增加（P大于0.05）。然而，在个体仔猪试验中，治疗仔猪（3.7%）的足部脓肿发生率显著低于未治疗仔猪（8%）（P = 0.01）。从腹泻、关节炎或足部脓肿仔猪分离出的需氧菌对OTC的最低抑菌浓度大于或等于64微克/毫升，或根据纸片扩散试验被归类为耐药。
