是否存在自然杀伤细胞记忆，能否通过疫苗接种加以利用？基于 NK 细胞和 ILC 记忆的疫苗接种策略。
Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Vaccination Strategies Based on NK Cell and ILC Memory.
机构信息
Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, St. Louis, Missouri 63110.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110.
出版信息
Cold Spring Harb Perspect Biol. 2018 Oct 1;10(10):a029512. doi: 10.1101/cshperspect.a029512.
Abstract
Studies over the last decade have decisively shown that innate immune natural killer (NK) cells exhibit enhanced long-lasting functional responses following a single activation event. With the increased recognition of memory and memory-like properties of NK cells, questions have arisen with regard to their ability to effectively mediate vaccination responses in humans. Moreover, recently discovered innate lymphoid cells (ILCs) could also potentially exhibit memory-like functions. Here, we review different forms of NK cell memory, and speculate about the ability of these cells and ILCs to meaningfully contribute to vaccination responses.
摘要
过去十年的研究已经明确表明，自然杀伤 (NK) 细胞在经历单次激活事件后，会表现出增强的、持久的功能反应。随着人们对 NK 细胞的记忆和类似记忆特性的认识不断提高，人们开始质疑它们在人类中有效介导疫苗反应的能力。此外，最近发现的先天淋巴细胞 (ILC) 也可能具有类似记忆的功能。在这里，我们回顾了 NK 细胞记忆的不同形式，并推测这些细胞和 ILC 对疫苗反应有意义的贡献能力。
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