Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, China.
Institute of Immunology, University of Science and Technology of China, Hefei, 230027, Anhui, China.
Cell Mol Immunol. 2019 May;16(5):423-429. doi: 10.1038/s41423-019-0212-6. Epub 2019 Feb 22.
Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ILC subsets: for example, NK cells recall haptens, viruses, and cytokines; ILC1s recall haptens; and ILC2s recall cytokines. Although the development and functions of ILCs mirror those of T-cell subsets, ILC and T-cell memory exhibit both common characteristics and specific properties. Encouragingly, ILC memory has been found to confer benefits in long-term tumor control and vaccination, providing insight for novel memory ILC-based tumor immunotherapy and vaccine-development strategies. In this review, we discuss the evidence supporting ILC memory and present a comprehensive framework of the ILC memory system.
先天淋巴细胞（ILC），包括自然杀伤（NK）细胞、ILC1、ILC2、ILC3 和淋巴组织诱导（LTi）细胞，构成了针对病原体和肿瘤的先天免疫防御的第一道防线。在过去的十年中，越来越多的证据表明 ILC 亚群具有免疫记忆：例如，NK 细胞回忆半抗原、病毒和细胞因子；ILC1 回忆半抗原；而 ILC2 回忆细胞因子。尽管 ILC 的发育和功能与 T 细胞亚群相似，但 ILC 和 T 细胞记忆表现出既有共同特征又有特定性质。令人鼓舞的是，已经发现 ILC 记忆可在长期肿瘤控制和疫苗接种中提供益处，为基于记忆 ILC 的肿瘤免疫治疗和疫苗开发策略提供了新的见解。在这篇综述中，我们讨论了支持 ILC 记忆的证据，并提出了 ILC 记忆系统的综合框架。
