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RGD与TAT共修饰的载多西他赛脂质体的制备与评价

Preparation and evaluation of RGD and TAT co-modified docetaxel-loaded liposome.

作者信息

Zhu Ren, Tian Ye

机构信息

Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou.

Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai.

出版信息

Drug Des Devel Ther. 2017 Dec 6;11:3481-3489. doi: 10.2147/DDDT.S149620. eCollection 2017.

DOI:10.2147/DDDT.S149620
PMID:29255349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5723111/
Abstract

The aim of this study is to develop a novel RGD and TAT co-modified docetaxel (DTX)-loaded liposome (LP) by the emulsification-solvent evaporation method. The prepared LPs were found to be in the size of 100 nm-110 nm. The transmission electron microscope photomicrographs were smooth, sub-spherical in shape, and aggregated to form small clusters. The DTX cumulative release from TAT and RGD co-modified LPs was significantly higher than that from other LPs due to decreased diffusion distance. Results of cell uptake showed that surface modification could indicate when cell internalization was changed and more drugs entered the cells successfully. Surprisingly, TAT and RGD co-modified DTX-LPs demonstrated a superior antiproliferative effect on A549 cells with a possible mechanism that suppressed the multidrug resistance phenomenon and exhibited a clear synergistic effect. In antitumor study, our results indicated that the form of TAT and RGD co-modified LPs had a better antitumor effect in vivo than the other formulations.

摘要

本研究的目的是通过乳化溶剂蒸发法开发一种新型的RGD和TAT共修饰的载多西他赛（DTX）脂质体（LP）。所制备的脂质体大小在100 nm至110 nm之间。透射电子显微镜照片显示其表面光滑，呈亚球形，且聚集形成小簇。由于扩散距离减小，TAT和RGD共修饰脂质体中DTX的累积释放量显著高于其他脂质体。细胞摄取结果表明，表面修饰可表明细胞内化何时发生变化，并且更多药物成功进入细胞。令人惊讶的是，TAT和RGD共修饰的DTX脂质体对A549细胞表现出优异的抗增殖作用，其可能机制是抑制多药耐药现象并表现出明显的协同作用。在抗肿瘤研究中，我们的结果表明，TAT和RGD共修饰脂质体在体内比其他制剂具有更好的抗肿瘤效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/2980dd2847b1/dddt-11-3481Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/1802d073efc1/dddt-11-3481Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/2f9b49372b71/dddt-11-3481Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/43df302af8be/dddt-11-3481Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/e8973da3a6c9/dddt-11-3481Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/a77da6dc3f38/dddt-11-3481Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/2980dd2847b1/dddt-11-3481Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/1802d073efc1/dddt-11-3481Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/2f9b49372b71/dddt-11-3481Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/43df302af8be/dddt-11-3481Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/e8973da3a6c9/dddt-11-3481Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/a77da6dc3f38/dddt-11-3481Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/5723111/2980dd2847b1/dddt-11-3481Fig6.jpg

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本文引用的文献

1
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Cancer. 2017 Dec 1;123(23):4672-4679. doi: 10.1002/cncr.30919. Epub 2017 Aug 17.
2
Cell-penetrating peptide conjugates to enhance the antitumor effect of paclitaxel on drug-resistant lung cancer.细胞穿透肽偶联物增强紫杉醇对耐药肺癌的抗肿瘤作用。
Drug Deliv. 2017 Nov;24(1):752-764. doi: 10.1080/10717544.2017.1321060.
3
Cell-Penetrating Peptides-Mechanisms of Cellular Uptake and Generation of Delivery Systems.
植物成分的抗癌活性及其针对肿瘤细胞和微环境的脂质体靶向策略。
Adv Drug Deliv Rev. 2020;154-155:245-273. doi: 10.1016/j.addr.2020.05.006. Epub 2020 May 28.
细胞穿透肽——细胞摄取机制与递送系统的生成
Pharmaceuticals (Basel). 2010 Mar 30;3(4):961-993. doi: 10.3390/ph3040961.
4
TAT Peptide-Conjugated Magnetic PLA-PEG Nanocapsules for the Targeted Delivery of Paclitaxel: In Vitro and Cell Studies.TAT 肽修饰的载紫杉醇磁性 PLA-PEG 纳米囊泡的靶向给药研究：体外与细胞实验。
AAPS PharmSciTech. 2017 Apr;18(3):769-781. doi: 10.1208/s12249-016-0560-9. Epub 2016 Jun 14.
5
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Colloids Surf B Biointerfaces. 2016 Aug 1;144:8-20. doi: 10.1016/j.colsurfb.2016.03.071. Epub 2016 Mar 26.
6
Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy.载有多西他赛的多层纳米颗粒及纳米液滴用于癌症治疗。
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7
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8
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Carbohydr Polym. 2016 Feb 10;137:65-74. doi: 10.1016/j.carbpol.2015.10.012. Epub 2015 Oct 23.
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Enhanced in vivo antitumor efficacy of dual-functional peptide-modified docetaxel nanoparticles through tumor targeting and Hsp90 inhibition.通过肿瘤靶向和 HSP90 抑制增强双功能肽修饰的多西紫杉醇纳米粒的体内抗肿瘤疗效。
J Control Release. 2016 Jan 10;221:26-36. doi: 10.1016/j.jconrel.2015.11.029. Epub 2015 Nov 28.