Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi, China.
Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Adv Drug Deliv Rev. 2020;154-155:245-273. doi: 10.1016/j.addr.2020.05.006. Epub 2020 May 28.
Various bioactive ingredients have been extracted from Chinese herbal medicines (CHMs) that affect tumor progression and metastasis. To further understand the mechanisms of CHMs in cancer therapy, this article summarizes the effects of five categories of CHMs and their active ingredients on tumor cells and the tumor microenvironment. Despite their treatment potential, the undesirable physicochemical properties (poor permeability, instability, high hydrophilicity or hydrophobicity, toxicity) and unwanted pharmacokinetic profiles (short half-life in blood and low bioavailability) restrict clinical studies of CHMs. Therefore, development of liposomes through relevant surface modifying techniques to achieve targeted CHM delivery for cancer cells, i.e., extracellular and intracellular targets and targets in tumor microenvironment or vasculature, have been reviewed. Current challenges of liposomal targeting of these phytoconstituents and future perspective of CHM applications are discussed to provide an informative reference for interested readers.
各种生物活性成分已从中草药（CHM）中提取出来，这些成分影响肿瘤的进展和转移。为了进一步了解 CHM 在癌症治疗中的机制，本文总结了五类 CHM 及其活性成分对肿瘤细胞和肿瘤微环境的影响。尽管 CHM 具有治疗潜力，但不理想的理化性质（较差的渗透性、不稳定性、高亲水性或疏水性、毒性）和不理想的药代动力学特征（血液半衰期短，生物利用度低）限制了 CHM 的临床研究。因此，通过相关的表面修饰技术开发脂质体，以实现对癌细胞、即细胞外和细胞内靶点以及肿瘤微环境或脉管系统中的靶点的靶向 CHM 递药，已经受到了研究。本文讨论了这些植物成分的脂质体靶向的当前挑战和 CHM 应用的未来展望，为感兴趣的读者提供了有价值的参考。
