Shakir Salika M, Powers-Fletcher Margaret V, Slechta E Susan, Fisher Mark A
Department of Pathology, University of Utah School of Medicine/ARUP Laboratories, Salt Lake City, UT, USA.
Department of Pathology, University of Cincinnati Medical Center, Cincinnati, OH, USA.
JMM Case Rep. 2017 Nov 8;4(11):e005126. doi: 10.1099/jmmcr.0.005126. eCollection 2017 Nov.
Invasive infections by are uncommon and occur primarily in immunocompromised patients. Here, we describe a case of bacteraemia and cellulitis in a patient with end-stage renal disease (ESRD). A 49-year-old male with ESRD on haemodialysis presented to an emergency department with cellulitis overlying his left upper extremity arteriovenous fistula for 3 days without constitutional symptoms. Mild leucocytosis and thrombocytopenia was noted on initial laboratory work up. The patient received a dose of vancomycin initially, and then transitioned to oral doxycycline prior to discharge 3 days later. Blood cultures drawn on admission were positive with curved Gram-negative rods at day 5. Routine sub-cultures initially failed to isolate the organism; however, small, tan colonies were observed on sheep blood agar incubated under microaerobic conditions. was identified by 16S rRNA sequencing. Antimicrobial-susceptibility testing was not performed due to poor growth and lack of interpretive guidelines. The patient was ultimately treated successfully with amoxicillin/clavulanic acid. This case illustrates the importance of recognizing infections in immunocompromised patients, especially in those with recent pet exposure. In addition, this case highlights the need for improved laboratory diagnostics for as isolation and identification of this fastidious organism is challenging.
[具体细菌名称]的侵袭性感染并不常见,主要发生在免疫功能低下的患者中。在此,我们描述一例终末期肾病(ESRD)患者发生[具体细菌名称]菌血症和蜂窝织炎的病例。一名49岁接受血液透析的ESRD男性因左上肢动静脉瘘上方出现蜂窝织炎3天就诊于急诊科,无全身症状。初始实验室检查发现轻度白细胞增多和血小板减少。患者最初接受了一剂万古霉素治疗,3天后出院前改为口服强力霉素。入院时采集的血培养在第5天培养出弯曲的革兰氏阴性杆菌。常规传代培养最初未能分离出该病原体;然而,在微需氧条件下孵育的羊血琼脂上观察到小的棕褐色菌落。通过16S rRNA测序鉴定出[具体细菌名称]。由于生长不佳且缺乏解释性指南,未进行药敏试验。该患者最终用阿莫西林/克拉维酸成功治疗。本病例说明了认识免疫功能低下患者中[具体细菌名称]感染的重要性,特别是那些近期接触过宠物的患者。此外,本病例凸显了改进[具体细菌名称]实验室诊断方法的必要性,因为分离和鉴定这种苛求菌具有挑战性。