Schmid Renee D, Hovda Lynn R
Pet Poison Helpline, 3600 American Blvd W #725, Bloomington, MN, 55431, USA.
J Med Toxicol. 2018 Jun;14(2):160-167. doi: 10.1007/s13181-017-0644-2. Epub 2017 Dec 18.
Mirabegron is a selective beta (B) adrenoreceptor agonist marketed for human treatment of an overactive bladder (OAB). It has a wide margin of safety in humans, but in dogs, severe adverse effects have occurred. We sought to determine the effects and outcome of mirabegron toxicosis in dogs. A retrospective review of all calls within the Pet Poison Helpline (PPH), an international animal poison control center, database was performed for mirabegron exposures between 2013 and 2015. Potential ingested doses ranging from 1.31 to 8.3 mg/kg. Many dogs remained asymptomatic and no fatalities occurred in any dogs. The most commonly reported signs were tachycardia and erythema. While mirabegron was found to have a very narrow margin of safety and high toxicity risk to dogs during preclinical trials, effects appear to differ greatly in the nonclinical field environment and further study is needed.
米拉贝隆是一种选择性β肾上腺素能受体激动剂，用于人类治疗膀胱过度活动症（OAB）。它在人类中有较宽的安全范围，但在犬类中会出现严重不良反应。我们试图确定米拉贝隆中毒对犬类的影响和结果。对国际动物中毒控制中心宠物中毒热线（PPH）数据库中2013年至2015年期间所有米拉贝隆暴露的记录进行了回顾性分析。潜在摄入剂量范围为1.31至8.3毫克/千克。许多犬只仍无症状，且无犬只死亡。最常报告的症状是心动过速和红斑。虽然在临床前试验中发现米拉贝隆对犬类的安全范围非常窄且毒性风险高，但在非临床野外环境中的影响似乎差异很大，需要进一步研究。
