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Mechanism of actions of Oncocin, a proline-rich antimicrobial peptide, in early elongation revealed by single-molecule FRET.

作者信息

Peng Sijia, Yang Mengyi, Sun Rui Ning, Liu Yang, Wang Wenjuan, Xi Qiaoran, Gong Haipeng, Chen Chunlai

机构信息

School of Life Sciences, Tsinghua University, Beijing, 100084, China.

Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing, 100084, China.

出版信息

Protein Cell. 2018 Oct;9(10):890-895. doi: 10.1007/s13238-017-0495-2.

DOI:10.1007/s13238-017-0495-2
PMID:29256010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6160386/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/669f/6160386/7f2340b8fdaa/13238_2017_495_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/669f/6160386/a0efa7b7933d/13238_2017_495_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/669f/6160386/7f2340b8fdaa/13238_2017_495_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/669f/6160386/a0efa7b7933d/13238_2017_495_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/669f/6160386/7f2340b8fdaa/13238_2017_495_Fig2_HTML.jpg

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Single-Molecule Photoactivation FRET: A General and Easy-To-Implement Approach To Break the Concentration Barrier.单分子光激活荧光共振能量转移：打破浓度障碍的通用且易于实施的方法。
Angew Chem Int Ed Engl. 2017 Jun 6;56(24):6882-6885. doi: 10.1002/anie.201702731. Epub 2017 May 11.
2
Pharmacokinetics and in vivo efficacy of optimized oncocin derivatives.优化后的癌抑素衍生物的药代动力学及体内疗效
J Antimicrob Chemother. 2016 Apr;71(4):1003-11. doi: 10.1093/jac/dkv454. Epub 2016 Jan 31.
3
Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
免疫：该基因编码两种具有特定病原体作用的宿主防御肽。
Proc Biol Sci. 2022 Jun 29;289(1977):20220773. doi: 10.1098/rspb.2022.0773. Epub 2022 Jun 22.
4
Intracellular mechanism of antimicrobial peptide HJH-3 against .抗菌肽HJH-3针对……的细胞内机制
RSC Adv. 2022 May 13;12(23):14485-14491. doi: 10.1039/d2ra01363k. eCollection 2022 May 12.
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Emerging peptide antibiotics with therapeutic potential.具有治疗潜力的新型肽类抗生素。
Med Drug Discov. 2021 Mar;9:100078. doi: 10.1016/j.medidd.2020.100078. Epub 2020 Dec 30.
与核糖体结合的富含脯氨酸的肽的结构揭示了蛋白质合成抑制的共同机制。
Nucleic Acids Res. 2016 Mar 18;44(5):2439-50. doi: 10.1093/nar/gkw018. Epub 2016 Jan 24.
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Nat Struct Mol Biol. 2015 Jun;22(6):466-9. doi: 10.1038/nsmb.3031. Epub 2015 May 18.
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