Faculty of Pharmacy, UMR 8076, BioCIS, Univ. Paris-Sud-CNRS, Université Paris-Saclay , 92290 Châtenay-Malabry, France.
J Org Chem. 2018 Jan 19;83(2):930-938. doi: 10.1021/acs.joc.7b02920. Epub 2018 Jan 2.
Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcohols is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions.
本文报道了 N-卤代琥珀酰亚胺在氟化醇中对芳烃和杂环的区域选择性卤化反应。在温和的条件下，该反应能以高区域选择性得到多种卤代芳烃，且产率良好。此外，通过一锅法串联卤化和卤化-铃木偶联反应，进一步证明了该方法的多功能性。
