Rajaram Prashanth, Chandra Poornima, Ticku Smriti, Pallavi B K, Rudresh K B, Mansabdar Poorva
Department of Oral and Maxillofacial Surgery, V. S. Dental College and Hospital, Bangalore, Karnataka, India.
Department of Oral Medicine and Radiology, Rajarajeswari Dental College and Hospital, Bangalore, Karnataka, India.
Indian J Dent Res. 2017 Nov-Dec;28(6):687-694. doi: 10.4103/ijdr.IJDR_534_16.
Cells are constantly exposed to various external stimuli which regulate the growth and survival of the cells. The signal transduction from the external environment to the interior of the cell is carried out by cell surface or transmembrane receptors. Epidermal growth factor receptor (EGFR) is a type I receptor tyrosine kinase and along with its ligands, EGFR is involved in the regulation of multiple cellular pathways. EGFR and its signaling pathway have been studied extensively for the biological and pathophysiological role in health and disease. There is enough evidence to suggest that EGFR is involved in the pathogenesis and progression of various cancers. This review discusses the structural anatomy and physiology of EGFR and its ligands, the role of EGFR in cancer and EGFR-targeted therapy.
细胞不断受到各种外部刺激，这些刺激调节着细胞的生长和存活。从外部环境到细胞内部的信号转导是由细胞表面或跨膜受体进行的。表皮生长因子受体（EGFR）是一种I型受体酪氨酸激酶，与它的配体一起，EGFR参与多种细胞途径的调节。EGFR及其信号通路在健康和疾病中的生物学和病理生理学作用已得到广泛研究。有充分证据表明EGFR参与各种癌症的发病机制和进展。本综述讨论了EGFR及其配体的结构解剖和生理学、EGFR在癌症中的作用以及EGFR靶向治疗。
