Cîmpeanu Ovidiu Lucian, Osman Andrei, Georgescu Alina Maria, Andrei Elena Cristina, Oprea Bogdan, Mateescu Valentin Octavian, Pătru Larisa, Mogoantă Carmen Aurelia, Tănase Ionuţ, Ciocâlteu Adriana Mihaela, Iovănescu Dan, Liliac Ilona Mihaela, Olteanu Mihai, Streba Costin Teodor
Department of Histology, University of Medicine and Pharmacy of Craiova, Romania;
Rom J Morphol Embryol. 2025 Jan-Mar;66(1):153-161. doi: 10.47162/RJME.66.1.14.
Globally, lung cancer is the primary cause of cancer-related mortality. Squamous cell carcinoma (SCC) of the lung, a subtype of non-small cell lung cancer (NSCLC), accounts for a significant portion of new cases and is primarily associated with smoking and environmental pollutants. This study investigates the histopathological and immunohistochemical (IHC) characteristics of the tumor microenvironment (TME) in SCC using tissue samples from 19 patients who underwent surgery for lung cancer. IHC markers, including cluster of differentiation (CD)68, CD3 and CD34 were used to assess various components of the TME, including immune cell infiltration, and angiogenesis. The results revealed significant presence of macrophages, T-lymphocytes, and myofibroblasts, as well as increased vascularization in the tumor stroma. These findings highlight the complex interaction between tumor cells and the surrounding stroma, contributing to tumor progression. Understanding these mechanisms is crucial for improving early diagnosis and therapeutic strategies for SCC.
在全球范围内，肺癌是癌症相关死亡的主要原因。肺鳞状细胞癌（SCC）是非小细胞肺癌（NSCLC）的一种亚型，占新发病例的很大一部分，主要与吸烟和环境污染物有关。本研究使用19例接受肺癌手术患者的组织样本，调查SCC中肿瘤微环境（TME）的组织病理学和免疫组织化学（IHC）特征。使用免疫组织化学标志物，包括分化簇（CD）68、CD3和CD34来评估TME的各种成分，包括免疫细胞浸润和血管生成。结果显示肿瘤基质中存在大量巨噬细胞、T淋巴细胞和成肌纤维细胞，以及血管生成增加。这些发现突出了肿瘤细胞与周围基质之间的复杂相互作用，促进了肿瘤进展。了解这些机制对于改善SCC的早期诊断和治疗策略至关重要。
