Department of Dermatology, Carol DavilaUniversity of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Biochemistry, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Nutrients. 2017 Dec 16;9(12):1365. doi: 10.3390/nu9121365.
Capsaicin is the main pungent in chili peppers, one of the most commonly used spices in the world; its analgesic and anti-inflammatory properties have been proven in various cultures for centuries. It is a lipophilic substance belonging to the class of vanilloids and an agonist of the transient receptor potential vanilloid 1 receptor. Taking into consideration the complex neuro-immune impact of capsaicin and the potential link between inflammation and carcinogenesis, the effect of capsaicin on muco-cutaneous cancer has aroused a growing interest. The aim of this review is to look over the most recent data regarding the connection between capsaicin and muco-cutaneous cancers, with emphasis on melanoma and muco-cutaneous squamous cell carcinoma.
辣椒素是辣椒中的主要辣味成分，也是世界上使用最广泛的香料之一；其镇痛和抗炎特性在多个文化中已被证实了数个世纪。它是一种亲脂性物质，属于香草醛类，并作为瞬时受体电位香草醛 1 型受体的激动剂。考虑到辣椒素对神经免疫的复杂影响，以及炎症与致癌之间的潜在联系，辣椒素对黏膜皮肤癌的影响引起了越来越多的关注。本综述的目的是回顾最近关于辣椒素与黏膜皮肤癌之间关联的数据，重点关注黑色素瘤和黏膜皮肤鳞状细胞癌。
