a Department of Neurology and Neurophysiology , University Hospital of North Norway , Tromsø , Norway.
b Department of Clinical Medicine , UiT - The Arctic University of Norway , Tromsø , Norway.
Scand J Clin Lab Invest. 2018 Feb-Apr;78(1-2):43-48. doi: 10.1080/00365513.2017.1408140. Epub 2017 Dec 19.
We investigated the association between serum creatine kinase (CK) and body fat mass in an overweight and obese population. In this cross-sectional study, 454 Caucasian overweight and obese individuals recruited from a medical outpatient clinic and via newspaper advertising underwent dual-energy X-ray absorptiometry (DEXA). Serum CK was obtained along with supplementary blood samples. This report is based on a secondary analysis from a previous randomized controlled trial treating obesity with vitamin D. Serum CK correlated negatively with body fat mass in men (r = -.18, p = .025) but not in women (r = -.11, p = .069). An insignificant negative trend for logCK across quartiles of fat mass in men was found (p = .098). CK did not associate significantly with lean mass, but lean mass correlated positively with fat mass in both groups (p < .0001). In a multivariate model, serum CK was inversely and independently related to fat mass in men. Fat mass decreased with 7.83 kg per unit logCK increase when adjusted for age and lean mass (95% CI -12.3 to -3.3, p = .001). These data support the view that circulating CK interacts with obesity in a favourable way independent of its muscular connection in men. CK was not associated with fat mass in women.
我们研究了超重和肥胖人群血清肌酸激酶（CK）与体脂肪量之间的关系。在这项横断面研究中，我们招募了 454 名来自医学门诊和报纸广告的白种超重和肥胖个体，他们接受了双能 X 射线吸收法（DEXA）检查。同时获得了血清 CK 和补充血液样本。本报告基于以前用维生素 D 治疗肥胖的随机对照试验的二次分析。血清 CK 与男性的体脂肪量呈负相关（r = -.18，p =.025），但与女性的体脂肪量无相关性（r = -.11，p =.069）。在男性中，发现 CK 对数与脂肪量四分位之间存在无统计学意义的负趋势（p =.098）。CK 与瘦体重无显著相关性，但在两组中，瘦体重与脂肪量呈正相关（p <.0001）。在多元模型中，血清 CK 与男性的脂肪量呈负相关且独立相关。当调整年龄和瘦体重时，CK 每增加一个单位，脂肪量就会减少 7.83kg（95%CI-12.3 至-3.3，p =.001）。这些数据支持了这样一种观点，即循环 CK 与肥胖以一种有利的方式相互作用，与男性的肌肉联系无关。CK 与女性的脂肪量无关。
