Haan Yentl C, Oudman Inge, Diemer Frederieke S, Karamat Fares A, van Valkengoed Irene G, van Montfrans Gert A, Brewster Lizzy M
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Mol Cell Endocrinol. 2017 Feb 15;442:24-31. doi: 10.1016/j.mce.2016.11.022. Epub 2016 Nov 25.
Creatine kinase (CK), the central regulatory enzyme of energy metabolism, is particularly high in type II skeletal muscle fibers, which are associated with insulin resistance and obesity. As resting plasma CK is mainly derived from skeletal muscle, we assessed whether plasma CK is associated with markers of obesity.
In this cross-sectional study, we analyzed a random sample of the multi-ethnic population of Amsterdam, the Netherlands, consisting of 1444 subjects aged 34-60 years. The primary outcome was the independent association between plasma CK after rest and waist circumference. Other outcomes included waist-to-hip ratio and body mass index.
Mean waist circumference increased from the first through the third CK tertile, respectively 90.3 (SD 13.4), 93.2 (SD 14.3), and 94.4 (SD 13.3) cm (p < 0.001 for differences between tertiles). The increase in waist circumference was 8.91 (95% CI 5.35 to 12.47) cm per log CK increase after adjustment for age, sex, African ethnicity, educational level, physical activity and plasma creatinine. Similarly, CK was independently associated with waist-to-hip ratio and body mass index, with an increase of respectively 0.05 (95% CI 0.03 to 0.07) and 3.6 (95% CI 2.3 to 5.0) kg/m per log CK increase.
Plasma CK is independently associated with measures of obesity in a multi-ethnic population. This is in line with the central role of type II skeletal muscle fibers in energy metabolism and obesity. Prospective studies should assess whether resting plasma CK could be an easy accessible marker of CK rich type II fiber predominance that helps identify individuals at risk for obesity.
肌酸激酶（CK）是能量代谢的核心调节酶，在与胰岛素抵抗和肥胖相关的II型骨骼肌纤维中含量特别高。由于静息血浆CK主要来源于骨骼肌，我们评估了血浆CK是否与肥胖标志物相关。
在这项横断面研究中，我们分析了荷兰阿姆斯特丹多民族人群的随机样本，其中包括1444名年龄在34至60岁之间的受试者。主要结局是静息后血浆CK与腰围之间的独立关联。其他结局包括腰臀比和体重指数。
平均腰围从CK三分位数的第一个到第三个分别增加，分别为90.3（标准差13.4）、93.2（标准差14.3）和94.4（标准差13.3）厘米（三分位数之间差异p < 0.001）。在调整年龄、性别、非洲族裔、教育水平、身体活动和血浆肌酐后，每增加一个对数CK，腰围增加8.91（95%可信区间5.35至12.47）厘米。同样，CK与腰臀比和体重指数独立相关，每增加一个对数CK，分别增加0.05（95%可信区间0.03至0.07）和3.6（可信区间2.3至5.0）千克/米。
在多民族人群中，血浆CK与肥胖指标独立相关。这与II型骨骼肌纤维在能量代谢和肥胖中的核心作用一致前瞻性研究应评估静息血浆CK是否可能是富含CK的II型纤维优势的易于获取的标志物，有助于识别肥胖风险个体。
