Achila Oliver Okoth, Semere Paulos, Andemichael Danait, Gherezgihier Harerta, Mehari Senait, Amanuel Adiam, Yohannes Tedalo, Yohaness Eyob, Goje Tzegezeab
Department of Clinical Laboratory Services, Asmara College of Health Sciences (ACHS), P.O. Box 9540, Asmara, Eritrea.
BMC Res Notes. 2017 Dec 19;10(1):748. doi: 10.1186/s13104-017-3087-6.
There is a scarcity of reference interval studies on the elderly in Africa. This study establishes reference interval for the elderly for some commonly used biochemical parameters. In this study, 255 conveniently sampled, healthy elderly, participants meeting Clinical and Laboratory Standards Institute (CLSI C28-A3) guidelines were enrolled. The results obtained may have utility in clinical diagnosis, patient management and research.
In general, the consensus reference interval established in this study tended to be higher than reference interval from Caucasian populations; but lower than those obtained from reference interval studies in several African countries. This pattern was observed in a number of analytes including Alanine aminotransferase; aspartate aminotransferase; alkaline phosphatase; sodium; potassium among others. Significant sex-related variations were also observed in total bilirubin; direct bilirubin; indirect bilirubin; albumin; sodium; chloride; plasma carbon dioxide, creatinine and anion gap. The results demonstrate that reference interval for Eritrean urban population differs from those derived from other African or North American populations. In this regard, the use of reference interval values obtained from Caucasian populations may result in misdiagnosis.
非洲针对老年人的参考区间研究匮乏。本研究建立了一些常用生化参数在老年人中的参考区间。在本研究中，招募了255名符合临床和实验室标准协会（CLSI C28 - A3）指南的方便抽样的健康老年人参与者。所获得的结果可能在临床诊断、患者管理和研究中具有实用价值。
总体而言，本研究建立的共识参考区间往往高于白种人群的参考区间，但低于在一些非洲国家进行的参考区间研究所得结果。在包括丙氨酸氨基转移酶、天冬氨酸氨基转移酶、碱性磷酸酶、钠、钾等多种分析物中均观察到这种模式。在总胆红素、直接胆红素、间接胆红素、白蛋白、钠、氯、血浆二氧化碳、肌酐和阴离子间隙方面也观察到显著的性别相关差异。结果表明，厄立特里亚城市人口的参考区间与其他非洲或北美人群的参考区间不同。在这方面，使用从白种人群获得的参考区间值可能会导致误诊。
