Ayemoba Ojor, Okeji Nathan, Hussain Nurudeen, Umar Tahir, Ajemba-Life Anthony, Kene Terfa, Edom Uchechukwu, Ogueri Ikechukwu, Nwagbara Goodluck, Ochai Inalegwu, Adekanye Usman, Onoh Ikenna
Ministry of Defence Health Implementation Programme, Abuja, Nigeria.
Ave Health Sense Ltd, Abuja, Nigeria.
PLoS One. 2021 Mar 1;16(3):e0247672. doi: 10.1371/journal.pone.0247672. eCollection 2021.
Reference intervals are assessment tools for interpretation of clinical test results. These intervals describe the dispersion of test parameter values of apparently healthy persons in defined populations as health status indicators. Using reference intervals obtained and validated in populations outside the geographical region of derivation for medical decision-making may impact negatively on clinical interpretation and patient management. Many countries have established their reference values, current studies on these data for Nigeria are however scarce. Determination of clinical biochemistry reference intervals for young Nigerian adults which is of particular importance in routine clinical management and conduct of clinical trials in response to existing and emerging diseases will add significantly to the existing body of knowledge.
The objective was to establish reference intervals for 24biochemistry analytes among Nigerians aged 18 to 26 years.
This was a cross-sectional study among 7,797 consenting male and female military applicants aged 18 to 26 years from 37 States of Nigeria. It was a total study among volunteers for military service. Blood samples were collected and subjected to serological testing for HIV-1 and 2, hepatitis-B, malaria, pregnancy and haematuria to restrict our study population to apparently healthy participants. Biochemical assays were performed on 6,169 participant samples that met the inclusion criteria. Generated data was entered into MS Excel® and exported into SPSS® software version 16 for analysis. Statistical tools used were frequencies, median, mid 95th percentile range with 2.5th and 97.5th percentiles as limits. Reference intervals were estimated using nonparametric methods. No intergender statistical comparison was made.
Complete records were obtained for 6,169 eligible participants. Median values and associated reference intervals were similar in both genders.
The findings from this study will help in clinical decision-making and play a significant role in supporting the current global rapid expansion of clinical trials in response to the urgent need for preventive and therapeutic solutions to existing and emerging diseases.
参考区间是用于解释临床检验结果的评估工具。这些区间将特定人群中看似健康者的检验参数值离散情况描述为健康状况指标。在医学决策中使用在数据来源地理区域之外的人群中获得并验证的参考区间，可能会对临床解释和患者管理产生负面影响。许多国家已经建立了各自的参考值，然而，目前针对尼日利亚这些数据的研究却很匮乏。确定尼日利亚年轻成年人的临床生物化学参考区间，这在常规临床管理以及针对现有和新出现疾病开展临床试验中尤为重要，将极大地丰富现有知识体系。
目的是确定18至26岁尼日利亚人24种生物化学分析物的参考区间。
这是一项横断面研究，研究对象为来自尼日利亚37个州的7797名年龄在18至26岁、自愿参与的男女应征入伍者。这是一项针对服兵役志愿者的全面研究。采集血样并进行HIV-1和2、乙型肝炎、疟疾、妊娠和血尿的血清学检测，以将研究人群限制为看似健康参与者。对符合纳入标准的6169名参与者样本进行生化检测。将生成的数据录入MS Excel®，并导出到SPSS®软件版本16进行分析。使用的统计工具包括频率、中位数、第95百分位数范围（以第2.5百分位数和第97.5百分位数为界限）。参考区间采用非参数方法估计。未进行性别间的统计比较。
获得了6169名符合条件参与者的完整记录。男女的中位数及相关参考区间相似。
本研究结果将有助于临床决策，并在支持当前全球因迫切需要针对现有和新出现疾病的预防和治疗解决方案而迅速扩大临床试验方面发挥重要作用。
