Wobudeya Eric, Sekadde-Kasirye Moorine, Kimuli Derrick, Mugabe Frank, Lukoye Deus
Mulago National Referral Hospital, Directorate of Paediatrics & Child health, Kampala, Uganda.
Ministry of Health, Uganda National TB & Leprosy Program, P. O. Box, 7272, Kampala, Uganda.
BMC Public Health. 2017 Dec 19;17(1):963. doi: 10.1186/s12889-017-4988-y.
The road map for childhood tuberculosis launched in 2013 provided strong renewed efforts focused towards zero deaths due to tuberculosis in children. From 2010, there were efforts to improve childhood tuberculosis diagnosis in Kampala and this study aimed to document the trend and outcome of tuberculosis in children over the period.
This was a retrospective study of tuberculosis data for Kampala city for the period 2011-2015. We extracted data from the unit TB registers in the 52 Diagnostic and treatment units (DTUs) in the Kampala. We report on data for children 0 to 14 years.
We accessed 33,221 TB patient records of which 2333 (7.0% 95% CI 6.7 to 7.3) were children. The proportion of children with pulmonary TB was 80% (1870/2333) (95% CI 76.7 to 83.7 and extra-pulmonary TB accounted for 20% (463/2333) (CI 18.3 to 21.5). Among pulmonary TB cases, the clinically diagnosed were 82% (1530/1870) (95% CI 80.0 to 83.5) while the bacteriologically confirmed were 18% (340/1870) (95% CI 16.5 to 20.0). Among the bacteriologically confirmed, 45% (154/340) (95% CI 40.1 to 50.6) were smear positive. During the study period 2011 through 2015, the childhood TB notification rate declined as follows; 105, 76, 72, 88, and 74 per 100,000 respectively. The treatment success rate increased from 78% in 2011 to 83% in 2015.
The TB notification rate among children in Kampala city showed a large decline during the period 2011 to 2015. There was a slight improvement in the treatment success rate among the children.
2013年推出的儿童结核病路线图为实现儿童结核病零死亡目标做出了新的有力努力。自2010年起，坎帕拉就开始努力改善儿童结核病的诊断情况，本研究旨在记录该时期儿童结核病的发病趋势和治疗结果。
这是一项对2011年至2015年坎帕拉市结核病数据的回顾性研究。我们从坎帕拉52个诊断和治疗单位（DTU）的结核病登记册中提取数据。我们报告0至14岁儿童的数据。
我们获取了33221份结核病患者记录，其中2333例（7.0%，95%置信区间6.7至7.3）为儿童。肺结核儿童的比例为80%（1870/2333）（95%置信区间76.7至83.7），肺外结核占20%（463/2333）（置信区间18.3至21.5）。在肺结核病例中，临床诊断的占82%（1530/1870）（95%置信区间80.0至83.5），细菌学确诊的占18%（340/1870）（95%置信区间16.5至20.0）。在细菌学确诊病例中，45%（154/340）（95%置信区间40.1至50.6）为涂片阳性。在2011年至2015年的研究期间，儿童结核病通报率下降情况如下：分别为每10万人105例、76例、72例、88例和74例。治疗成功率从2011年的78%提高到2015年的83%。
2011年至2015年期间，坎帕拉市儿童结核病通报率大幅下降。儿童治疗成功率略有提高。
