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David 和 Bentall 手术治疗急性 A 型主动脉夹层的 16 年经验。

Sixteen-Year Experience of David and Bentall Procedures in Acute Type A Aortic Dissection.

机构信息

Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan.

Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan.

出版信息

Ann Thorac Surg. 2018 Mar;105(3):779-784. doi: 10.1016/j.athoracsur.2017.09.029. Epub 2017 Dec 16.

Abstract

BACKGROUND

To examine short-term and midterm outcomes after the David and Bentall procedures in patients with an acute type A aortic dissection.

METHODS

Between 2001 and 2017, patients (n = 135) with acute type A aortic dissection underwent an aortic root replacement with either the David (n = 40) or Bentall (n = 95) procedure. Perioperative outcome, reoperation rate, aortic valve function, and long-term survival were evaluated.

RESULTS

The median age of the entire cohort was 56 years. Rates of malperfusion (21%), shock (16%), history of renal failure (4%), and extent of surgery were similar between David and Bentall groups. However, the David group was significantly younger (45 versus 61 years) with less hypertension (45% versus 66%), coronary artery disease (0% versus 17%), valvulopathy (5% versus 19%), and prior cardiac surgery (5% versus 21%). Overall operative mortality was 9.6% (David 3% and Bentall 13%). Composite outcome comprising myocardial infarction, stroke, new-onset renal failure, and operative mortality was 18% in the entire cohort (David 5% and Bentall 23%). In the David group, the freedom of moderate aortic insufficiency was 95% at 10 years. The rate of reoperation for pathology of the proximal aorta or aortic valve was 0% and 2% for the David and Bentall groups, respectively. Ten-year Kaplan-Meier survival was 66% (95% confidence interval: 51% to 77%) for the entire cohort, with 98% (95% confidence interval: 84% to 99%) survival in the David group and 57% (95% confidence interval: 42% to 70%) survival in the Bentall group.

CONCLUSIONS

Both the David and Bentall procedures are appropriate surgical approaches for aortic root replacement in select patients with an acute type A aortic dissection.

摘要

背景

研究急性 A 型主动脉夹层患者行 David 和 Bentall 手术后的短期和中期结果。

方法

2001 年至 2017 年间,135 例急性 A 型主动脉夹层患者行主动脉根部置换术,其中 40 例行 David 手术(David 组),95 例行 Bentall 手术(Bentall 组)。评估围手术期结局、再次手术率、主动脉瓣功能和长期生存率。

结果

全组患者中位年龄为 56 岁。David 组和 Bentall 组的血运不良发生率(21%对 16%)、休克发生率(16%对 16%)、肾衰竭史发生率(4%对 17%)和手术范围相似。然而,David 组患者更年轻(45 岁对 61 岁),高血压(45%对 66%)、冠心病(0%对 17%)、瓣叶病变(5%对 19%)和既往心脏手术(5%对 21%)更少。全组手术死亡率为 9.6%(David 组 3%,Bentall 组 13%)。复合终点包括心肌梗死、卒中和新发肾衰竭以及手术死亡率在全组为 18%(David 组 5%,Bentall 组 23%)。在 David 组,10 年时中度主动脉瓣关闭不全的无事件生存率为 95%。David 组和 Bentall 组因近端主动脉或主动脉瓣病变而再次手术的发生率分别为 0%和 2%。全组 10 年 Kaplan-Meier 生存率为 66%(95%置信区间:51%至 77%),David 组为 98%(95%置信区间:84%至 99%),Bentall 组为 57%(95%置信区间:42%至 70%)。

结论

David 和 Bentall 手术都是急性 A 型主动脉夹层患者行主动脉根部置换术的合适手术方法。

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