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动脉瘤或夹层患者主动脉根部修复:保留瓣膜的根部置换术与Bentall手术的疗效比较

Repair of aortic root in patients with aneurysm or dissection: comparing the outcomes of valve-sparing root replacement with those from the Bentall procedure.

作者信息

Skripochnik Edvard, Michler Robert E, Hentschel Viktoria, Neragi-Miandoab Siyamek

出版信息

Rev Bras Cir Cardiovasc. 2013 Oct-Dec;28(4):435-41. doi: 10.5935/1678-9741.20130072.

Abstract

INTRODUCTION

Management of aortic root aneurysm or dissection has been the subject of much discussion that has led to some modifications. The current trend is a valve-sparing root replacement. We compared the outcome following valve sparing root repair with Bentall procedure.

METHODS

We retrospectively evaluated 70 patients who underwent root replacement for aneurysm or dissection and compared the outcomes of valve-sparing root replacement with those of the Bentall procedure from January 2007 to December 2011 at our institution.

RESULTS

Twenty-five patients had valve-sparing aortic root replacement (VSR, including reimplantation or remodeling) (23 males and 2 females), and 45 patients had the Bentall procedure (34 males and 11 females). Patients who underwent a VSR were younger with a mean age of 55.4 ± 14.8 years compared to those who underwent the Bentall procedure with a mean age of 60.6 ± 12.7 (P=ns). The preoperative aortic insufficiency (AI) in the VSR group was moderate in 8 (32%) patients, and severe in 6 (24%). Preoperative creatinine was 1 ± 0.35 mg/dl in the VSR group and 1.1 ± 0.87 mg/dl in the Bentall group. In the VSR group, 3 (12%) patients had emergency surgery; by contrast, in the Bentall group, 8 (17%) patients had emergent surgery. Concomitant coronary artery bypass grafting (excluding coronary reimplantation) was performed in 8 (32%) patients in the VSR group and in 12 (26.6%) patients in the Bentall group (P=0.78); additional valve procedures were performed in 2 (8%) patients in the VSR group and in 11 (24.4%) patients in the Bentall group. The perioperative mortality was 8% (n=2) and 13.3% (n=6), for the VSR and Bentall procedures, respectively (P=0.7, ns). The total duration of intensive care unit stay was 116.6 ± 106 hours for VSR patients and 152.5 ± 218.2 hours for Bentall patients (P=0.5). The overall length of stay in the hospital was 10 ± 8.1 days for VSR and 11 ± 9.52 days for Bentall (P=0.89). The one-year survival was 92% for the VSR group and 79.0% for the Bentall group. The seven-year survival for the VSR group was 92% and 79% for the Bentall group (95% CI [1.215 to 0.1275], P=0.1).

CONCLUSION

Aortic valve-sparing root replacement can be performed with acceptable morbidity and mortality with a comparable long-term survival to the Bentall procedure.

摘要

引言

主动脉根部瘤或夹层的治疗一直是诸多讨论的主题,这些讨论带来了一些改变。当前的趋势是保留瓣膜的根部置换术。我们比较了保留瓣膜根部修复术与Bentall手术的结果。

方法

我们回顾性评估了70例行根部置换术治疗动脉瘤或夹层的患者,并比较了2007年1月至2011年12月在我院接受保留瓣膜根部置换术与Bentall手术患者的结果。

结果

25例患者接受了保留瓣膜的主动脉根部置换术(VSR,包括再植入或重塑)(23例男性和2例女性),45例患者接受了Bentall手术(34例男性和11例女性)。接受VSR的患者较年轻,平均年龄为55.4±14.8岁,而接受Bentall手术的患者平均年龄为60.6±12.7岁(P=无显著差异)。VSR组术前主动脉瓣关闭不全(AI)为中度的有8例(32%),重度的有6例(24%)。VSR组术前肌酐为1±0.35mg/dl,Bentall组为1.1±0.87mg/dl。VSR组有3例(12%)患者接受了急诊手术;相比之下,Bentall组有8例(17%)患者接受了急诊手术。VSR组8例(32%)患者进行了同期冠状动脉旁路移植术(不包括冠状动脉再植入),Bentall组12例(26.6%)患者进行了该手术(P=0.78);VSR组2例(8%)患者进行了额外的瓣膜手术,Bentall组11例(24.4%)患者进行了该手术。VSR和Bentall手术的围手术期死亡率分别为8%(n=2)和13.3%(n=6)(P=0.7,无显著差异)。VSR患者重症监护病房住院总时长为116.6±106小时,Bentall患者为152.5±218.2小时(P=0.5)。VSR患者住院总时长为10±8.1天,Bentall患者为11±9.52天(P=0.89)。VSR组1年生存率为92%,Bentall组为79.0%。VSR组7年生存率为92%,Bentall组为79%(95%可信区间[1.215至0.1275],P=0.1)。

结论

保留主动脉瓣的根部置换术可在可接受的发病率和死亡率情况下进行,长期生存率与Bentall手术相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24a/4389436/b2ecb4e78db8/rbccv-28-04-0435-g01.jpg

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