Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, P. R. China.
Regenerative Medicine Research Center, West China Hospital, Sichuan University, Keyuan Road 4, Gaopeng Street, Chengdu, Sichuan, 610041, P. R. China.
Nutr Diabetes. 2017 Dec 19;7(12):2. doi: 10.1038/s41387-017-0002-0.
Insulin-like growth factor 1 (IGF1) is a key factor for tissue growth and fuel metabolism. The potential function of central IGF1 remains unclear. We previously observed that IGF1 expression is increased in the hypothalamus of obese mice lacking STAT5 in the central nervous system (CNS). In this study, we explored the potential metabolic function of central IGF1 by intracerebroventricular (ICV) injection of IGF1, over-expression of central IGF1 by administering an adeno-associated virus (AAV), and ICV injection of an anti-IGF1 antibody. Mice that over-expressed central IGF1 displayed increased appetite, improved glucose tolerance and insulin sensitivity, decreased Pomc levels in the hypothalamus, and increased UCP1 expression in brown fat tissue. This is the first study demonstrating that central IGF1 regulates several important metabolic functions.
胰岛素样生长因子 1（IGF1）是组织生长和燃料代谢的关键因素。中枢 IGF1 的潜在功能尚不清楚。我们之前观察到，缺乏中枢神经系统（CNS）中 STAT5 的肥胖小鼠的下丘脑 IGF1 表达增加。在这项研究中，我们通过脑室内（ICV）注射 IGF1、通过给予腺相关病毒（AAV）过表达中枢 IGF1 和脑室内注射抗 IGF1 抗体来探索中枢 IGF1 的潜在代谢功能。过表达中枢 IGF1 的小鼠表现出食欲增加、葡萄糖耐量和胰岛素敏感性改善、下丘脑 Pomc 水平降低以及棕色脂肪组织 UCP1 表达增加。这是第一项表明中枢 IGF1 调节几种重要代谢功能的研究。
