Bonet M Luisa, Mercader Josep, Palou Andreu
Laboratory of Molecular Biology, Nutrition and Biotechnology - Group of Nutrigenomics and Obesity (NUO), Universitat de les Illes Balears, Palma de Mallorca and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Spain.
Alimentómica S.L, Palma de Mallorca, Spain.
Biochimie. 2017 Mar;134:99-117. doi: 10.1016/j.biochi.2016.12.014. Epub 2017 Jan 3.
Uncoupling protein 1 (UCP1) is the hallmark protein responsible for cold- and diet-induced thermogenesis in brown adipose tissue (BAT). UCP1 activity is protective against body fat accumulation. UCP1 has re-gained researchers' attention in the context of obesity following the realization that BAT is present and can be activated in adult humans and of inducible UCP1-expressing cells in white fat depots. UCP1-mediated thermogenesis is activated by specific food compounds, which function by stimulating sympathetic nervous system activity to adipose tissues and/or by acting on the adipose cells directly or indirectly, through humoral factors released upon their intake. The impact, functional consequences and potential mechanism of action of macronutrients, micronutrients and bioactive compounds impinging on UCP1 expression/activity is discussed, as well as emerging links between human genetic variation and differential responses to potential thermogenic food ingredients. Advances in this field can help dietary recommendations and strategies for long-term weight loss/maintenance and improved metabolic health.
解偶联蛋白1（UCP1）是棕色脂肪组织（BAT）中负责寒冷和饮食诱导产热的标志性蛋白。UCP1活性可防止体脂积累。在认识到成人中存在BAT且其可被激活，以及白色脂肪库中存在可诱导表达UCP1的细胞后，UCP1在肥胖背景下重新引起了研究人员的关注。UCP1介导的产热由特定食物化合物激活，这些化合物通过刺激交感神经系统对脂肪组织的活性和/或通过直接或间接作用于脂肪细胞来发挥作用，其作用途径是通过摄入后释放的体液因子。本文讨论了大量营养素、微量营养素和生物活性化合物对UCP1表达/活性的影响、功能后果和潜在作用机制，以及人类基因变异与对潜在产热食物成分的不同反应之间的新联系。该领域的进展有助于制定长期减肥/维持体重和改善代谢健康的饮食建议和策略。
