Nakamura Mayumi, Yamashita Yoshiki, Hayashi Atsushi, Saito Natsuho, Yu Masae, Hayashi Masami, Terai Yoshito, Ohmichi Masahide
Department of Obstetrics and Gynecology Osaka Medical College Osaka Japan.
Miyazaki Ladies Clinic Osaka Japan.
Reprod Med Biol. 2016 Dec 26;16(1):40-44. doi: 10.1002/rmb2.12004. eCollection 2017 Jan.
To investigate which risk factors contribute to a lower oocyte retrieval ratio in women who are receiving controlled ovarian hyperstimulation.
The authors retrospectively analyzed 329 in vitro fertilization (IVF) cycles under controlled ovarian hyperstimulation by using a gonadotropin-releasing hormone antagonist or agonist at Osaka Medical College, Japan. The patients were classified into five groups: advanced age, male infertility, severe endometriosis, tubal infertility, and unexplained infertility. The primary outcomes were the patients' age, oocyte retrieval ratio, serum basal follicle-stimulating hormone, total dose of gonadotropin, and the clinical outcome. A secondary outcome was the stepwise multivariate logistic regression analysis to assess the factors associated with the failure of oocyte retrieval.
The oocyte retrieval ratio declined significantly with the patient's age. The ratio of endometriosis in unsuccessful cases was significantly higher than that in successful cycles. Advanced age and endometriosis were the factors that were significantly associated with a lowered oocyte retrieval rate.
Advanced age and endometriosis are high-risk factors that contribute to oocyte retrieval failure in infertile patients who are receiving IVF treatment.
探讨在接受控制性卵巢刺激的女性中，哪些风险因素会导致较低的卵母细胞采集率。
作者回顾性分析了日本大阪医学院329个使用促性腺激素释放激素拮抗剂或激动剂进行控制性卵巢刺激的体外受精（IVF）周期。患者被分为五组：高龄、男性不育、重度子宫内膜异位症、输卵管性不育和不明原因不育。主要结局指标为患者年龄、卵母细胞采集率、血清基础促卵泡激素、促性腺激素总剂量及临床结局。次要结局指标为逐步多因素逻辑回归分析，以评估与卵母细胞采集失败相关的因素。
卵母细胞采集率随患者年龄显著下降。未成功病例中子宫内膜异位症的比例显著高于成功周期。高龄和子宫内膜异位症是与卵母细胞采集率降低显著相关的因素。
高龄和子宫内膜异位症是导致接受IVF治疗的不孕患者卵母细胞采集失败的高危因素。
