Department of Obstetrics and Gynaecology, Faculty of Clinical Sciences, College of Medicine, Kaduna State University/Barau Dikko Teaching Hospital, Kaduna, Nigeria.
Nisa Premier Hospital/Institute of Medical Sciences, Abuja, Nigeria.
Pan Afr Med J. 2024 Apr 16;47:190. doi: 10.11604/pamj.2024.47.190.38674. eCollection 2024.
the availability of oocytes is fundamental to in vitro fertilization (IVF). The factors associated with optimal or suboptimal oocyte recovery rates (ORR) in low-resource settings are not well known. This study aimed to determine the factors associated with ORR by comparing demographic and IVF cycle data of women undergoing IVF in our Centre.
this was a prospective study of 110 infertile women undergoing IVF at Nisa Premier Hospital, Abuja Nigeria, from October 2020 to September 2021. All women had reached the stage of oocyte retrieval or further, after receiving ovarian stimulation with our routine protocols. Treatment was monitored by serial transvaginal ultrasonography. The oocyte retrieval procedures were performed under conscious sedation, 36 hours after the ovulatory trigger. Optimal ORR was when eggs were obtained from at least 80% of follicles punctured. Sub-optimal ORR was when it was less than 80%. Data analyses utilized SPSS statistical software and a p-value of < 0.05 was considered significant.
the mean age of all women was 34.1±4.9 years. Sixty-nine women (62.7%) had sub-optimal ORR while 41 (37.3%) had optimal ORR. Six women (5.5%) had no oocytes retrieved. Significantly more women with sub-optimal ORR were obese (70.6 vs 29.4%) and had higher follicle-stimulating hormone (FSH) levels (8.11 vs 6.34 miu/ml), p-value- 0.039. Women with sub-optimal ORR had higher mean prolactin levels (17.10 ± 13.93 miu/ml) than women with optimal ORR 11.43 ± 6.65 miu/ml), p-value- 0.019). Significantly more oocytes (5.99 vs 10.37, p-value 0.001), and MII oocytes (5.78 vs 7.56, p-value 0.035) were retrieved in women with optimal than sub-optimal ORR. The duration of stimulation, total amounts of gonadotropins administered, and fertilized oocytes were not significantly different among both groups (p-value >0.05).
this study has shown the factors associated with ORR in our setting to be basal FSH, prolactin, and obesity.
卵子的可用性是体外受精（IVF）的基础。在资源匮乏的环境中，与最佳或次优卵母细胞回收率（ORR）相关的因素尚不清楚。本研究旨在通过比较我们中心接受 IVF 的女性的人口统计学和 IVF 周期数据，确定与 ORR 相关的因素。
这是一项前瞻性研究，纳入了 2020 年 10 月至 2021 年 9 月在尼日利亚阿布贾 Nisa Premier 医院接受 IVF 的 110 名不孕女性。所有女性在接受我们常规方案的卵巢刺激后，均已进入卵母细胞采集或进一步治疗阶段。通过连续经阴道超声监测治疗情况。在排卵诱导后 36 小时，在清醒镇静下进行卵母细胞采集。当至少 80%的穿刺卵泡获得卵子时，认为 ORR 为最佳。当 ORR 低于 80%时，认为 ORR 为次优。数据分析采用 SPSS 统计软件，p 值<0.05 为差异有统计学意义。
所有女性的平均年龄为 34.1±4.9 岁。69 名女性（62.7%）的 ORR 为次优，41 名女性（37.3%）的 ORR 为最佳。6 名女性（5.5%）未获得卵母细胞。ORR 次优的女性肥胖（70.6% vs 29.4%）和卵泡刺激素（FSH）水平较高（8.11 vs 6.34 miu/ml）的比例显著更高，p 值为 0.039。ORR 次优的女性催乳素水平（17.10 ± 13.93 miu/ml）高于 ORR 最佳的女性（11.43 ± 6.65 miu/ml），p 值为 0.019。ORR 最佳的女性获得的卵母细胞（5.99 个 vs 10.37 个，p 值为 0.001）和 MII 卵母细胞（5.78 个 vs 7.56 个，p 值为 0.035）均显著多于 ORR 次优的女性。两组之间的刺激持续时间、促性腺激素总用量和受精卵母细胞数无显著差异（p 值>0.05）。
本研究表明，我们研究环境中与 ORR 相关的因素是基础 FSH、催乳素和肥胖。
