• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Evidence of B-cell dysregulation in severe CNS inflammation after alemtuzumab therapy.

作者信息

Rinaldi Francesca, Federle Lisa, Puthenparampil Marco, Perini Paola, Grassivaro Francesca, Gallo Paolo

机构信息

Multiple Sclerosis Centre, University Hospital, Department of Neuroscience DNS, University of Padova, Italy.

出版信息

Neurol Neuroimmunol Neuroinflamm. 2017 Dec 13;5(1):e420. doi: 10.1212/NXI.0000000000000420. eCollection 2018 Jan.

DOI:10.1212/NXI.0000000000000420
PMID:29259997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5730817/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a1b/5730817/9af487cd4c7c/NEURIMMINFL2017013862f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a1b/5730817/9af487cd4c7c/NEURIMMINFL2017013862f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a1b/5730817/9af487cd4c7c/NEURIMMINFL2017013862f1.jpg

相似文献

1
Evidence of B-cell dysregulation in severe CNS inflammation after alemtuzumab therapy.阿仑单抗治疗后严重中枢神经系统炎症中B细胞失调的证据。
Neurol Neuroimmunol Neuroinflamm. 2017 Dec 13;5(1):e420. doi: 10.1212/NXI.0000000000000420. eCollection 2018 Jan.
2
Alemtuzumab-induced remission of both severe paraneoplastic pemphigus and leukaemic bone marrow infiltration in a case of treatment-resistant B-cell chronic lymphocytic leukaemia.在一例难治性B细胞慢性淋巴细胞白血病患者中，阿仑单抗诱导严重副肿瘤性天疱疮和白血病骨髓浸润均获缓解。
Eur J Haematol. 2004 Sep;73(3):206-9. doi: 10.1111/j.1600-0609.2004.00280.x.
3
Alemtuzumab for B-cell chronic lymphocytic leukemia.阿仑单抗用于B细胞慢性淋巴细胞白血病
Expert Rev Anticancer Ther. 2008 Jul;8(7):1033-51. doi: 10.1586/14737140.8.7.1033.
4
Cytomegalovirus reactivation during alemtuzumab therapy for chronic lymphocytic leukemia: incidence and treatment with oral ganciclovir.阿仑单抗治疗慢性淋巴细胞白血病期间的巨细胞病毒再激活：发病率及口服更昔洛韦治疗
Haematologica. 2004 Oct;89(10):1248-52.
5
Immunity 12 years after alemtuzumab in RA: CD5⁺ B-cell depletion, thymus-dependent T-cell reconstitution and normal vaccine responses.类风湿关节炎患者使用阿仑单抗12年后的免疫情况：CD5⁺ B细胞耗竭、胸腺依赖性T细胞重建及正常疫苗反应
Rheumatology (Oxford). 2012 Aug;51(8):1397-406. doi: 10.1093/rheumatology/kes038. Epub 2012 Mar 24.
6
Routine clinical use of alemtuzumab in patients with heavily pretreated B-cell chronic lymphocytic leukemia: a nation-wide retrospective study in Austria.阿仑单抗在经过大量预处理的B细胞慢性淋巴细胞白血病患者中的常规临床应用：奥地利一项全国性回顾性研究
Cancer. 2006 Nov 15;107(10):2408-16. doi: 10.1002/cncr.22263.
7
Intense reversal of bone marrow angiogenesis after sequential fludarabine-induction and alemtuzumab-consolidation therapy in advanced chronic lymphocytic leukemia.在晚期慢性淋巴细胞白血病中，氟达拉滨诱导序贯阿仑单抗巩固治疗后骨髓血管生成的强烈逆转。
Haematologica. 2007 Oct;92(10):1367-74.
8
Delayed allograft inflammation following alemtuzumab induction for kidney transplantation.肾移植中使用阿仑单抗诱导后发生的移植物延迟炎症。
Clin Transplant. 2013 Sep-Oct;27(5):772-80. doi: 10.1111/ctr.12201. Epub 2013 Aug 8.
9
Both cladribine and alemtuzumab may effect MS via B-cell depletion.克拉屈滨和阿仑单抗均可通过清除B细胞来影响多发性硬化症。
Neurol Neuroimmunol Neuroinflamm. 2017 Jun 5;4(4):e360. doi: 10.1212/NXI.0000000000000360. eCollection 2017 Jul.
10
[Guidelines for alemtuzumab treatment in chronic lymphocytic leukaemia (CLL)].
Vnitr Lek. 2012 Mar;58(3):232-6.

引用本文的文献

1
The immunological bases of alemtuzumab as induction-therapy in pediatric-onset multiple sclerosis.阿仑单抗作为儿童起病型多发性硬化诱导治疗的免疫学基础。
Front Immunol. 2025 Jan 8;15:1509987. doi: 10.3389/fimmu.2024.1509987. eCollection 2024.
2
Case report: tumefactive demyelinating lesions after the second cycle of alemtuzumab in multiple sclerosis; immune cell profile and biomarkers.病例报告：多发性硬化症患者在接受第二次阿仑单抗治疗后出现肿块样脱髓鞘病变；免疫细胞特征和生物标志物。
Front Immunol. 2024 Jul 3;15:1395749. doi: 10.3389/fimmu.2024.1395749. eCollection 2024.
3
Alemtuzumab following natalizumab is more effective in adult-onset than paediatric-onset multiple sclerosis.

本文引用的文献

1
Tumefactive demyelination following treatment for relapsing multiple sclerosis with alemtuzumab.用阿仑单抗治疗复发型多发性硬化症后出现的肿胀性脱髓鞘病变。
Neurology. 2017 Mar 7;88(10):1004-1006. doi: 10.1212/WNL.0000000000003694. Epub 2017 Feb 8.
2
Severe B-cell-mediated CNS disease secondary to alemtuzumab therapy.阿仑单抗治疗继发的严重B细胞介导的中枢神经系统疾病。
Lancet Neurol. 2017 Feb;16(2):104-106. doi: 10.1016/S1474-4422(16)30382-9.
3
Circulating immune cells in multiple sclerosis.多发性硬化症中的循环免疫细胞。
在那他珠单抗之后使用阿仑单抗，对成人起病型多发性硬化症的疗效比对儿童起病型多发性硬化症更好。
Ther Adv Neurol Disord. 2023 Oct 6;16:17562864231177196. doi: 10.1177/17562864231177196. eCollection 2023.
4
COVID-19: dealing with a potential risk factor for chronic neurological disorders.COVID-19：应对慢性神经障碍的潜在风险因素。
J Neurol. 2021 Apr;268(4):1171-1178. doi: 10.1007/s00415-020-10131-y. Epub 2020 Aug 27.
5
Managing Risks with Immune Therapies in Multiple Sclerosis.多发性硬化症的免疫治疗风险管理。
Drug Saf. 2019 May;42(5):633-647. doi: 10.1007/s40264-018-0782-8.
6
Restoration of regulatory B cell deficiency following alemtuzumab therapy in patients with relapsing multiple sclerosis.在复发型多发性硬化症患者中，阿仑单抗治疗后调节性 B 细胞缺陷的恢复。
J Neuroinflammation. 2018 Oct 30;15(1):300. doi: 10.1186/s12974-018-1334-y.
Clin Exp Immunol. 2017 Feb;187(2):193-203. doi: 10.1111/cei.12878. Epub 2016 Nov 2.
4
CD83 Modulates B Cell Activation and Germinal Center Responses.CD83调节B细胞活化和生发中心反应。
J Immunol. 2016 May 1;196(9):3581-94. doi: 10.4049/jimmunol.1502163. Epub 2016 Mar 16.
5
Circulating CCR7+ICOS+ Memory T Follicular Helper Cells in Patients with Multiple Sclerosis.多发性硬化症患者循环中的CCR7 + ICOS +记忆性滤泡辅助性T细胞
PLoS One. 2015 Jul 31;10(7):e0134523. doi: 10.1371/journal.pone.0134523. eCollection 2015.
6
Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis.循环滤泡调节性T细胞在多发性硬化症中存在缺陷。
J Immunol. 2015 Aug 1;195(3):832-40. doi: 10.4049/jimmunol.1500759. Epub 2015 Jun 12.
7
Long term lymphocyte reconstitution after alemtuzumab treatment of multiple sclerosis.多发性硬化症患者接受阿仑单抗治疗后的淋巴细胞长期重建。
J Neurol Neurosurg Psychiatry. 2012 Mar;83(3):298-304. doi: 10.1136/jnnp-2011-300826. Epub 2011 Nov 5.