Department of General Practice and Elderly Care Medicine and Amsterdam Public Health Research Institute, VU University Medical Center, Van der Boechorststraat 7, room D-534, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.
Department of Health Sciences and Amsterdam Public Health Research Institute, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Room U-430, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands.
Eur J Health Econ. 2018 Sep;19(7):993-1008. doi: 10.1007/s10198-017-0947-x. Epub 2017 Dec 19.
Differences between country-specific guidelines for economic evaluations complicate the execution of international economic evaluations. The aim of this study was to develop cross-European recommendations for the identification, measurement and valuation of resource use and lost productivity in economic evaluations using a Delphi procedure.
A comprehensive literature search was conducted to identify European guidelines on the execution of economic evaluations or costing studies as part of economic evaluations. Guideline recommendations were extracted by two independent reviewers and formed the basis for the first round of the Delphi study, which was conducted among European health economic experts. During three written rounds, consensus (agreement of 67% or higher) was sought on items concerning the identification, measurement and valuation of costs.
Recommendations from 18 guidelines were extracted. Consensus among 26 panellists from 17 European countries was reached on 61 of 68 items. The recommendations from the Delphi study are to adopt a societal perspective, to use patient report for measuring resource use and lost productivity, to value both constructs with use of country-specific standardized/unit costs and to use country-specific discounting rates.
This study provides consensus-based cross-European recommendations on how to measure and value resource use and lost productivity in economic evaluations. These recommendations are expected to support researchers, healthcare professionals, and policymakers in executing and appraising economic evaluations performed in international contexts.
国家特定指南之间的差异使国际经济评估变得复杂。本研究旨在通过德尔菲程序为欧洲制定用于经济评估中资源利用和生产力损失的识别、测量和估值的跨欧洲建议。
进行了全面的文献检索，以确定有关经济评估或成本研究执行的欧洲指南，作为经济评估的一部分。两名独立审查员提取了指南建议，并将其作为欧洲健康经济专家参与的第一轮德尔菲研究的基础。在三轮书面轮次中，就涉及成本识别、测量和估值的项目达成共识（同意率达到 67%或更高）。
从 18 项指南中提取了建议。来自 17 个欧洲国家的 26 名小组成员就 68 项中的 61 项达成了共识。德尔菲研究的建议是采用社会视角，使用患者报告来衡量资源利用和生产力损失，使用特定国家/地区的标准化/单位成本来衡量这两个结构，并使用特定国家/地区的贴现率。
本研究提供了基于共识的欧洲跨地区建议，用于在经济评估中测量和估值资源利用和生产力损失。这些建议有望为在国际背景下进行经济评估的研究人员、医疗保健专业人员和政策制定者提供支持。
