Department of Neuroscience, Institute of Health Sciences, Dokuz Eylül University, Izmir, Turkey.
Department of Neurology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.
J Neurol. 2018 Feb;265(2):381-387. doi: 10.1007/s00415-017-8712-8. Epub 2017 Dec 19.
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a common, treatable, autoimmune peripheral neuropathy considered to produce imbalance by weakness and proprioceptive impairment rather than vestibular impairment. We measured semicircular canal vestibular function in 21 CIDP patients (15M/6F) by the video head impulse test and postural stability with a battery comprising the modified Clinical Test of Sensory Integration and Balance, the Berg Balance Scale, the Dynamic Gait Index, the Fall Efficiency Scale, and the International Cooperative Ataxia Rating Scale. Of the 21 patients, 16 had vestibular impairment, ranging from mild-affecting just a single semicircular canal, to severe-affecting all 6 canals. Although the severity of the vestibular impairment did not correlate either with the severity of the postural imbalance or of the peripheral neuropathy, our data show that vestibular impairment is an additional challenge to balance that some CIDP patients will face.
慢性炎症性脱髓鞘性多发性神经病（CIDP）是一种常见的、可治疗的自身免疫性周围神经病，据认为它会通过无力和本体感觉障碍而不是前庭障碍导致平衡失调。我们通过视频头脉冲试验测量了 21 例 CIDP 患者（15 例男性/6 例女性）的半规管前庭功能，并通过包含改良临床感觉综合和平衡测试、伯格平衡量表、动态步态指数、跌倒效率量表和国际合作共济失调评分的电池来测量姿势稳定性。在这 21 名患者中，有 16 名存在前庭功能障碍，从仅影响单个半规管的轻度到影响所有 6 个半规管的重度不等。尽管前庭功能障碍的严重程度与姿势失衡或周围神经病的严重程度均无相关性，但我们的数据表明，前庭功能障碍是 CIDP 患者可能面临的另一种平衡挑战。
