Meliones J N, Beekman R H, Rocchini A P, Lacina S J
Ann Arbor, Michigan 48109-0204.
J Am Coll Cardiol. 1989 Apr;13(5):1106-10. doi: 10.1016/0735-1097(89)90269-6.
The immediate and intermediate-term effects of balloon valvuloplasty were assessed at cardiac catheterization in nine children with recurrent stenosis after a previous surgical aortic valvotomy. At valvuloplasty the patients ranged in age from 0.35 to 16 years and had undergone surgical valvotomy 0.3 to 12.5 years previously. Balloon valvuloplasty immediately reduced the peak systolic aortic stenosis gradient by 53%, from 88 +/- 9 (mean +/- SEM) to 41 +/- 6 mm Hg (p = 0.004). The left ventricular systolic pressure was reduced from 189 +/- 8 to 157 +/- 8 mm Hg (p = 0.001) and the left ventricular end-diastolic pressure from 17 +/- 1 to 14 +/- 2 mm Hg (p = 0.025). The heart rate and cardiac index remained unchanged. Before valvuloplasty, one patient had 1 + and two patients had 2+ aortic insufficiency. In six of nine patients, balloon valvuloplasty caused no change in the degree of valvular insufficiency. Two patients had a 1 + increase (from 0 to 1 + insufficiency in both), and one patient with no insufficiency developed 2+ aortic insufficiency. Elective follow-up catheterization was performed 0.8 to 2.5 years (mean 1.5 +/- 0.2) after valvuloplasty. At follow-up, the peak aortic stenosis gradient remained significantly reduced from the gradient before valvuloplasty (37 +/- 5 versus 85 +/- 10 mm Hg, p = 0.002). The gradient had not changed significantly from that measured immediately after valvuloplasty (37 +/- 5 versus 38 +/- 5 mm Hg, p = 0.75). At follow-up, aortic insufficiency had decreased from that immediately after valvuloplasty in three patients and had increased in two.(ABSTRACT TRUNCATED AT 250 WORDS)
对9例既往接受过主动脉瓣切开术且出现复发性狭窄的儿童,在心脏导管插入术时评估球囊瓣膜成形术的即刻和中期效果。接受瓣膜成形术时,患者年龄在0.35至16岁之间,先前接受手术瓣膜切开术的时间为0.3至12.5年。球囊瓣膜成形术使收缩期主动脉狭窄峰值梯度立即降低53%,从88±9(均值±标准误)降至41±6 mmHg(p = 0.004)。左心室收缩压从189±8降至157±8 mmHg(p = 0.001),左心室舒张末期压力从17±1降至14±2 mmHg(p = 0.025)。心率和心脏指数保持不变。瓣膜成形术前,1例患者有1+主动脉瓣关闭不全,2例患者有2+主动脉瓣关闭不全。9例患者中有6例,球囊瓣膜成形术未改变瓣膜关闭不全的程度。2例患者的瓣膜关闭不全程度增加1+(均从0变为1+),1例无瓣膜关闭不全的患者出现2+主动脉瓣关闭不全。在瓣膜成形术后0.8至2.5年(平均1.5±0.2年)进行了选择性随访导管插入术。随访时,主动脉狭窄峰值梯度仍显著低于瓣膜成形术前的梯度(37±5与85±10 mmHg,p = 0.002)。该梯度与瓣膜成形术后即刻测量的值相比无显著变化(37±5与38±5 mmHg,p = 0.75)。随访时,3例患者的主动脉瓣关闭不全程度较瓣膜成形术后即刻有所减轻,2例患者的主动脉瓣关闭不全程度有所加重。(摘要截短于250字)