多功能 Cu-AgS 纳米粒子，具有高光热转换效率，可用于体内光声成像引导的光热治疗。

Multifunctional Cu-AgS nanoparticles with high photothermal conversion efficiency for photoacoustic imaging-guided photothermal therapy in vivo.

机构信息

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.

出版信息

Nanoscale. 2018 Jan 3;10(2):825-831. doi: 10.1039/c7nr07263e.

DOI:10.1039/c7nr07263e

PMID:29260827

Abstract

Photothermal therapy (PTT) has attracted increasing interest and become widely used in cancer therapy owing to its noninvasiveness and low level of systemic adverse effects. However, there is an urgent need to develop biocompatible and multifunctional PTT agents with high photothermal conversion efficiency. Herein, biocompatible Cu-AgS/PVP nanoparticles (NPs) with strong near-infrared absorption and high photothermal conversion efficiency were successfully synthesized for high-performance photoacoustic (PA) imaging-guided PTT in vivo. The novel Cu-AgS/PVP NPs feature high photothermal conversion efficiency (58.2%) under 808 nm light irradiation, noticeably higher than those of most reported PTT agents. Because of their good dispersibility, Cu-AgS/PVP NPs passively accumulate within tumors via the enhanced permeability and retention effect, which can be confirmed by PA imaging, photothermal performance, and biodistribution in vivo. Furthermore, Cu-AgS/PVP NPs are thoroughly cleared through feces and urine within seven days, indicating a high level of biosafety for further potential clinical translation.

摘要

光热疗法（PTT）由于其非侵入性和低全身不良反应水平，引起了越来越多的关注，并已广泛应用于癌症治疗。然而，迫切需要开发具有高光热转换效率的生物相容性和多功能 PTT 试剂。在此，成功合成了具有强近红外吸收和高光热转换效率的生物相容性 Cu-AgS/PVP 纳米颗粒（NPs），用于体内高性能光声（PA）成像引导的 PTT。在 808nm 光照射下，新型 Cu-AgS/PVP NPs 表现出高的光热转换效率（58.2%），明显高于大多数报道的 PTT 试剂。由于其良好的分散性，Cu-AgS/PVP NPs 通过增强的通透性和保留效应被动地在肿瘤内积累，可以通过 PA 成像、光热性能和体内分布来证实。此外，Cu-AgS/PVP NPs 在七天内通过粪便和尿液被彻底清除，表明其具有很高的生物安全性，可进一步潜在地用于临床转化。