Dong Caihong, Feng Wei, Xu Wenwen, Yu Luodan, Xiang Huiijng, Chen Yu, Zhou Jianqiao
Department of Ultrasound Zhongshan Hospital Fudan University Shanghai 200032 P. R. China.
School of Life Sciences Shanghai University Shanghai 200444 P. R. China.
Adv Sci (Weinh). 2020 Aug 16;7(21):2001549. doi: 10.1002/advs.202001549. eCollection 2020 Nov.
As an essential trace element in the human body, transitional metal copper (Cu) ions are the bioactive components within the body featuring dedicated biological effects such as promoting angiogenesis and influencing lipid/glucose metabolism. The recent substantial advances of nanotechnology and nanomedicine promote the emerging of distinctive Cu-involved biomaterial nanoplatforms with intriguing theranostic performances in biomedicine, which are originated from the biological effects of Cu species and the physiochemical attributes of Cu-composed nanoparticles. Based on the very-recent significant progresses of Cu-involved nanotheranostics, this work highlights and discusses the principles, progresses, and prospects on the elaborate design and rational construction of Cu-composed functional nanoplatforms for a diverse array of biomedical applications, including photonic nanomedicine, catalytic nanotherapeutics, antibacteria, accelerated tissue regeneration, and bioimaging. The engineering of Cu-based nanocomposites for synergistic nanotherapeutics is also exemplified, followed by revealing their intrinsic biological effects and biosafety for revolutionizing their clinical translation. Finally, the underlying critical concerns, unresolved hurdles, and future prospects on their clinical uses are analyzed and an outlook is provided. By entering the "Copper Age," these Cu-involved nanotherapeutic modalities are expected to find more broad biomedical applications in preclinical and clinical phases, despite the current research and developments still being in infancy.
作为人体必需的微量元素，过渡金属铜（Cu）离子是体内具有特定生物学效应的生物活性成分，如促进血管生成和影响脂质/葡萄糖代谢。纳米技术和纳米医学的最新重大进展推动了独特的含铜生物材料纳米平台的出现，这些平台在生物医学中具有引人入胜的诊疗性能，这源于铜物种的生物学效应和含铜纳米颗粒的物理化学特性。基于含铜纳米诊疗学的最新重大进展，本文重点介绍并讨论了用于多种生物医学应用（包括光子纳米医学、催化纳米治疗、抗菌、加速组织再生和生物成像）的含铜功能纳米平台的精心设计和合理构建的原理、进展和前景。还举例说明了用于协同纳米治疗的铜基纳米复合材料的工程设计，随后揭示了它们的内在生物学效应和生物安全性，以推动其临床转化。最后，分析了其临床应用中潜在的关键问题、未解决的障碍和未来前景，并给出了展望。尽管目前的研究和开发仍处于起步阶段，但通过进入“铜时代”，这些含铜纳米治疗方式有望在临床前和临床阶段找到更广泛的生物医学应用。
