Feng Xin, Li Mingjun, Wang Jianming, Zou Xianrui, Wang Hongshui, Wang Donghui, Zhou Huan, Yang Lei, Gao Wei, Liang Chunyong
Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China.
Center for Health Science and Engineering, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China.
Materials (Basel). 2022 Jun 28;15(13):4543. doi: 10.3390/ma15134543.
It is critical to construct stimuli-responsive multifunctional nanoparticles for the drug delivery system for cancer treatment. Zeolitic imidazolate framework-8 (ZIF-8) has a large specific surface area and decomposes quickly under acidic conditions, which presents an excellent potential in pH-sensitive drug carriers. However, the mere chemotherapeutic drug loaded into ZIF-8 is a monotherapy and may restrict the therapeutic efficacy of malignancies. In this work, an effective nanoparticle-based delivery platform is established to simultaneously encapsulate doxorubicin (DOX) and MXene quantum dot (MQD) in ZIF-8 nanoparticles (MQD@ZIF-8/DOX). Under near-infrared (NIR) laser (808 nm) and UV light (365 nm) irradiation, MQD@ZIF-8 demonstrates a high photothermal conversion efficiency and reactive oxygen species (ROS) production, which shows excellent photothermal therapy and photodynamic therapy effects. Furthermore, the release of DOX-loaded into MQD@ZIF-8 nanoparticles is significantly increased under NIR laser irradiation and at pH 5.6, indicating that acidic conditions and NIR laser irradiation can be effectively combined to stimulate the drug release. The cellular experiments show that MQD@ZIF-8/DOX has an obvious killing effect on HeLa cells and achieves the combined anti-tumor effect of chemotherapy and phototherapy.
构建用于癌症治疗药物递送系统的刺激响应性多功能纳米颗粒至关重要。沸石咪唑酯骨架-8（ZIF-8）具有大的比表面积且在酸性条件下快速分解，这使其在pH敏感药物载体方面具有优异的潜力。然而，单纯负载到ZIF-8中的化疗药物属于单一疗法，可能会限制恶性肿瘤的治疗效果。在这项工作中，建立了一种基于纳米颗粒的有效递送平台，将阿霉素（DOX）和MXene量子点（MQD）同时封装在ZIF-8纳米颗粒（MQD@ZIF-8/DOX）中。在近红外（NIR）激光（808 nm）和紫外光（365 nm）照射下，MQD@ZIF-8表现出高的光热转换效率和活性氧（ROS）生成，显示出优异的光热疗法和光动力疗法效果。此外，负载在MQD@ZIF-8纳米颗粒中的DOX在NIR激光照射和pH 5.6条件下释放显著增加，表明酸性条件和NIR激光照射可有效结合以刺激药物释放。细胞实验表明，MQD@ZIF-8/DOX对HeLa细胞具有明显的杀伤作用，并实现了化疗和光疗的联合抗肿瘤效果。
