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对来自西番莲叶片的内生真菌弯孢瓶霉产生的代谢产物进行化学研究。

Chemical investigation of metabolites produced by an endophytic fungi Phialemonium curvatum from the leaves of Passiflora edulis.

作者信息

Rathnayake G R Nalin, Kumar N Savitri, Jayasinghe Lalith, Araya Hiroshi, Fujimoto Yoshinori

机构信息

a National Institute of Fundamental Studies , Kandy , Sri Lanka.

b School of Agriculture , Meiji University , Kawasaki , Japan.

出版信息

Nat Prod Res. 2018 Oct;32(20):2483-2486. doi: 10.1080/14786419.2017.1416373. Epub 2017 Dec 20.

Abstract

Phialemonium curvatum, an endophytic fungus isolated from the leaves of Passiflora edulis was cultured in potato dextrose broth (PDB) media and chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of 4-hydroxybenzoic acid (1), 3-indole acetic acid (2), solaniol (3), uracil (4), uridine (5) and glycerol (6). Compound 2 showed a weak antifungal activity against Cladosporium cladosporioides. This is the first report of the isolation of the endophytic fungus P. curvatum from P. edulis and complete CNMR assignments of 3.

摘要

弯孢瓶霉是从西番莲叶片中分离得到的一种内生真菌,将其在马铃薯葡萄糖肉汤(PDB)培养基中培养,对肉汤和菌丝体的乙酸乙酯提取物进行色谱分离,得到了4-羟基苯甲酸(1)、3-吲哚乙酸(2)、茄呢醇(3)、尿嘧啶(4)、尿苷(5)和甘油(6)。化合物2对枝孢霉显示出微弱的抗真菌活性。这是首次报道从西番莲中分离出内生真菌弯孢瓶霉以及化合物3的完整碳核磁共振谱归属。

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