Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
Antiaging Center, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
Molecules. 2017 Dec 20;22(12):2279. doi: 10.3390/molecules22122279.
In our continuing study of biologically active natural products from the fruit of (Zingiberaceae), we newly isolated three new labdane-type diterpenes, termed galangalditerpenes A-C (-), along with four known sesquiterpenes (-) and two diterpenes ( and ). The stereostructures of - were elucidated on the basis of their spectroscopic properties. The melanogenesis inhibitory activities in theophylline-stimulated murine B16 melanoma 4A5 cells of these isolates, including the new diterpenes (-, IC = 4.4, 8.6, and 4.6 μM, respectively), were found to be more than 6-87-fold higher than that of arbutin (174 μM), a commercially available positive control.
在对（姜科）果实中具有生物活性的天然产物的持续研究中，我们新分离得到三种新的贝壳杉烷型二萜，命名为姜醛二萜 A-C（-），以及四种已知的倍半萜（-）和两种二萜（和）。根据光谱特性阐明了-的立体结构。这些分离物在茶碱刺激的小鼠 B16 黑色素瘤 4A5 细胞中的黑色素生成抑制活性，包括新的二萜（-，IC = 4.4、8.6 和 4.6 μM），比熊果苷（174 μM）高出 6-87 倍以上，熊果苷是一种市售的阳性对照。
