来自硬叶桉的 rearranged phloroglucinol-monoterpenoid adducts。
Rearranged Phloroglucinol-Monoterpenoid Adducts from Callistemon rigidus.
机构信息
Institute of Traditional Chinese Medicine & Natural Products and ‡Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University , Guangzhou 510632, People's Republic of China.
出版信息
J Nat Prod. 2018 Jan 26;81(1):57-62. doi: 10.1021/acs.jnatprod.7b00606. Epub 2017 Dec 20.
Callisretones A (1) and B (2), two rearranged phloroglucinol-monoterpenoid adducts featuring an unprecedented isopropylcyclopenta[b]benzofuran backbone, together with their postulated biosynthetic precursors (3-9), were isolated from Callistemon rigidus. The previously assigned absolute configurations of viminalins H (7), L (8), and N (9) were revised and unequivocally established by X-ray diffraction data. A putative biosynthetic pathway toward callisretones A and B involving the rearrangement of the terpenoid motif is proposed. In addition, 1 and 2 showed inhibitory effects on nitric oxide production with IC values of 15.3 ± 1.0 and 17.7 ± 1.1 μM, respectively.
Callisretones A (1) 和 B (2) 是两种重排的苯丙素-单萜类加合物，具有前所未有的异丙基环戊 [b] 苯并呋喃骨架，以及它们假定的生物合成前体 (3-9)，从 Callistemon rigidus 中分离出来。以前分配给 viminalins H (7)、L (8) 和 N (9) 的绝对构型已通过 X 射线衍射数据进行了修订并明确确定。提出了一种涉及萜类化合物重排的假定生物合成途径，生成 callisretones A 和 B。此外，1 和 2 对一氧化氮的产生表现出抑制作用，IC 值分别为 15.3 ± 1.0 和 17.7 ± 1.1 μM。
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