State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , People's Republic of China.
J Nat Prod. 2018 May 25;81(5):1252-1259. doi: 10.1021/acs.jnatprod.8b00087. Epub 2018 May 9.
Fractionation of an aqueous extract of the air-dried roots of a traditional Chinese medicinal plant, Paeonia lactiflora, yielded the new monoterpenoid glycosides 1-10. Their structures were assigned via spectroscopic techniques, and the absolute configurations of 1, 4-6, and 8 were verified via chemical methods, specific rotation, and electronic circular dichroism data. Compounds 1-4 are rare compared to the reported cage-like paeoniflorin derivatives; that is, they comprised two monoterpenoidal moieties. In the in vitro assay, compounds 5, 8, and 9 showed weak inhibitions against lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages, with IC values of 64.8, 60.1, and 97.5 μM, respectively.
从传统中药白芍的干燥根的水提物中分离得到了 10 种新的单萜苷类化合物 1-10。通过光谱技术确定了它们的结构，通过化学方法、比旋光度和电子圆二色性数据确定了 1、4-6 和 8 的绝对构型。与报道的笼状芍药苷衍生物相比，化合物 1-4 较为罕见，它们由两个单萜部分组成。在体外试验中，化合物 5、8 和 9 对 RAW264.7 巨噬细胞中脂多糖诱导的一氧化氮生成表现出较弱的抑制作用，IC 值分别为 64.8、60.1 和 97.5 μM。
