Maeta M, Karino T, Inoue Y, Hamazoe R, Shimizu N, Koga S
First Department of Surgery, Tottori University School of Medicine, Yonago, Japan.
Int J Hyperthermia. 1989 Mar-Apr;5(2):191-7. doi: 10.3109/02656738909140447.
The selective enhancement of drug delivery to tumours is an important factor in the effectiveness of thermochemotherapy as well as in standard normothermal chemotherapy. We have attempted to clarify experimentally using AH 100B tumour-bearing rats whether or not a selective increase in blood flow in tumours can be produced under specific conditions of local hyperthermia by administration of angiotensin (AGT II). AGT II (2 micrograms/kg/min) produced an elevation of blood pressure (ca. 150 mm Hg) when local hyperthermia, at 41, 43, and 45 degrees C, was induced. Furthermore, at 41 and 43 degrees C a selective increase in blood flow in tumours resulted from the AGT II-induced hypertension. By contrast, a decrease in blood flow was observed at 45 degrees C both in tumour and in muscle. These results indicate that AGT II-induced hypertension and the resultant selective increase in drug delivery to tumours during the initial phase of heating may result in an augmentation of the anticancer effects of thermochemotherapy.
药物向肿瘤部位的选择性递送增强，是热化疗有效性以及标准常温化疗有效性的一个重要因素。我们试图通过实验，利用荷AH 100B肿瘤大鼠来阐明，在局部热疗的特定条件下，给予血管紧张素（AGT II）是否能够使肿瘤内血流量选择性增加。当诱导41、43和45摄氏度的局部热疗时，AGT II（2微克/千克/分钟）会使血压升高（约150毫米汞柱）。此外，在41和43摄氏度时，AGT II诱导的高血压导致肿瘤内血流量选择性增加。相比之下，在45摄氏度时，肿瘤和肌肉中的血流量均减少。这些结果表明，AGT II诱导的高血压以及加热初始阶段由此导致的药物向肿瘤的选择性递送增加，可能会增强热化疗的抗癌效果。
