Karino T, Koga S, Maeta M
First Department of Surgery, Tottori University School of Medicine, Yonago, Japan.
Jpn J Surg. 1988 May;18(3):276-83. doi: 10.1007/BF02471444.
The heat-induced environmental changes in tumor tissues are considered to influence the antitumor effect of hyperthermia or hyperthermochemotherapy, which is believed to complement the direct lethal effect of heat on tumor cells. The effects of local hyperthermia on the blood flow, oxygen pressure and pH in tissues were investigated using AH-100B tumor bearing rats, by immersing the tumor in a water bath at 41 degrees, 43 degrees and 45 degrees C. These parameters were measured in the marginal and deeper sites of the tumor mass, and in the normal muscle adjacent to the tumor. During immersion at 41 degrees C, blood flow in the tissue was increased at each site, and during immersion at 43 degrees C, tissue blood flow increased initially at each site, but decreased with time to rates below that of the unheated tissue. During immersion at 45 degrees C, the blood flow decreased markedly in each tissue. The changes in oxygen pressure and pH in each tissue were similar to those observed in the blood flow during localized heating at 41 degrees, 43 degrees and 45 degrees C. In local thermochemotherapy, the initial stage of hyperthermic treatment seems to be the most suitable time for administering carcinostatics, since it is the time when tumor blood flow has not yet decreased.
肿瘤组织中热诱导的环境变化被认为会影响热疗或热化疗的抗肿瘤效果，而热疗或热化疗被认为可补充热对肿瘤细胞的直接致死作用。使用AH - 100B荷瘤大鼠，通过将肿瘤浸入41℃、43℃和45℃的水浴中，研究了局部热疗对组织中血流、氧分压和pH值的影响。在肿瘤块的边缘和深部以及肿瘤附近的正常肌肉中测量这些参数。在41℃浸泡期间，各部位组织中的血流均增加；在43℃浸泡期间，各部位组织血流最初增加，但随时间下降至低于未加热组织的水平。在45℃浸泡期间，各组织中的血流明显减少。在41℃、43℃和45℃局部加热期间，各组织中氧分压和pH值的变化与血流变化相似。在局部热化疗中，热疗的初始阶段似乎是给予抗癌药的最合适时间，因为此时肿瘤血流尚未减少。
