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慢性创伤性脑病(存档)

Chronic Traumatic Encephalopathy(Archived)

作者信息

Inserra Christopher J., DeVrieze Bradley W.

机构信息

Creighton University

Creighton University School of Medicine

Abstract

Sports-related traumatic brain injury (TBI) has become increasingly popular in the scientific literature over the past few decades.However, the first mention of such a subject in the literature occurred in the 1920s with reference to the “punch drunk” syndrome of boxers. About a decade later, the term “dementia pugilistica,” which literally means “boxer’s dementia,” was born. The now more commonly used term chronic traumatic encephalopathy (CTE) was coined later in the 1940s.This term has gained favor in the modern literature because it is now understood that exposure to TBI from any sport or source increases the risk for neurodegenerative disease first described in boxers. While there has been some effort to distinguish dementia pugilistica from CTE or to classify dementia pugilistica as a subtype of CTE, the two are now widely considered to be equivalent. Thus, while the term dementia pugilistica is certainly of historical significance, this article will focus on the neurodegenerative disease resulting from (mainly sports-related) TBI that is now most commonly referred to as CTE.

摘要

在过去几十年里,与运动相关的创伤性脑损伤(TBI)在科学文献中越来越受关注。然而,文献中首次提及这一主题是在20世纪20年代,当时提到了拳击手的“拳击醉态”综合征。大约十年后,“拳击性痴呆”一词诞生,其字面意思是“拳击手痴呆”。现在更常用的术语“慢性创伤性脑病”(CTE)是在20世纪40年代后期创造的。这个术语在现代文献中受到青睐,因为现在人们明白,来自任何运动或来源的TBI暴露都会增加患神经退行性疾病的风险,这种疾病最初在拳击手中被描述。虽然有人试图将拳击性痴呆与CTE区分开来,或将拳击性痴呆归类为CTE的一种亚型,但现在人们普遍认为两者是等同的。因此,虽然“拳击性痴呆”这个术语当然具有历史意义,但本文将重点关注由(主要与运动相关的)TBI导致的神经退行性疾病,这种疾病现在最常被称为CTE。

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Neurological consequences of traumatic brain injuries in sports.运动中创伤性脑损伤的神经学后果。
Mol Cell Neurosci. 2015 May;66(Pt B):114-22. doi: 10.1016/j.mcn.2015.03.012. Epub 2015 Mar 12.
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