Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
Sci Rep. 2017 Dec 20;7(1):17894. doi: 10.1038/s41598-017-18039-w.
We introduced a new method for detecting iris surface furrows and identify its associations with dynamic changes in iris volume in healthy eyes. Swept-source optical coherence tomography was performed on 65 subjects with open angle under light and dark conditions. Iris boundaries were identified and a reconstruction of the anterior iris surface was obtained. Furrows were detected by identifying locally deep (minima) points on the iris surface and reported as furrow length in millimetres. Iris volume was quantified. Associations between furrow length and dynamic changes in iris volume were assessed using linear regression model. With pupil dilation, furrow length increased (15.84 mm) whereas iris volume decreased (-1.19 ± 0.66 mm). Longer furrow length was associated with larger static iris volume, as well as smaller loss of iris volume with pupil dilation (β = -0.10, representing 0.1 mm less loss in iris volume per 10 mm increase in iris furrow length; P = 0.002, adjusted for age, gender and changes in pupil size). Our iris furrow length measurements are robust and intuitive. Eyes with longer furrows have larger iris volume and lose less volume during physiological pupil dilation. These findings highlight the potential for iris surface features as indicators of iris morphological behavior.
我们介绍了一种新的方法来检测虹膜表面的皱襞，并确定其与健康眼睛中虹膜体积的动态变化之间的关联。对 65 名受试者在明、暗两种条件下进行了扫频光学相干断层扫描。识别虹膜边界并获得前虹膜表面的重建。通过识别虹膜表面的局部深（极小）点来检测皱襞，并以毫米为单位报告皱襞长度。量化虹膜体积。使用线性回归模型评估皱襞长度与虹膜体积动态变化之间的关联。随着瞳孔扩张，皱襞长度增加（15.84 毫米），而虹膜体积减少（-1.19±0.66 毫米）。较长的皱襞长度与较大的静态虹膜体积以及瞳孔扩张时虹膜体积减少较小相关（β=-0.10，代表每增加 10 毫米虹膜皱襞长度，虹膜体积减少 0.1 毫米；P=0.002，调整年龄、性别和瞳孔大小变化后）。我们的虹膜皱襞长度测量结果是稳健和直观的。具有较长皱襞的眼睛具有更大的虹膜体积，并且在生理瞳孔扩张期间体积减少较少。这些发现强调了虹膜表面特征作为虹膜形态行为指标的潜力。
