Fujihara Yuya, Nawata Hajime, Honda Masanao, Kunitake Tsuyoshi, Aida Eiji, Nagai Tetsu, Kuramochi Hitoshi, Ueno Junichi, Yoshimoto Shoji, Muta Kazuo
Medical Corp.Seiwakai Muta Hospital Fukuoka Japan.
J Gen Fam Med. 2017 May 8;18(5):237-243. doi: 10.1002/jgf2.56. eCollection 2017 Oct.
Associations between vascular calcification and osteoporosis are well documented, yet effects of lifestyle on atherosclerosis and osteoporosis remain unclear. This study evaluated the relationship between atherosclerosis and osteoporosis of people with different lifestyles living on Uku Island in Japan (rice consumption and fishing lifestyle) and in Ulaanbaatar in Mongolia (meat consumption and nomadic lifestyle), and investigated the differences of lifestyles on atherosclerosis and osteoporosis.
Participants were women aged over 50 years who had undergone a previous medical examination for atherosclerosis and osteoporosis (Uku Island, 104, Ulaanbaatar, 71). Lifestyle habits were obtained by questionnaire. Bone mineral density of the right calcaneus was measured using quantitative ultrasound. Brachial-ankle pulse wave velocity was measured as an index of atherosclerosis.
There were no significant differences in bone mineral density and brachial-ankle pulse wave velocity between the two groups, even though meat and dairy intake, number of meals skipped, and number of children were significantly greater in participants from Ulaanbaatar compared with Uku Island. Brachial-ankle pulse wave velocity showed significant positive correlations with age, systolic and diastolic blood pressures, and body mass index and a significant negative correlation with bone mineral density for both groups. With step-wise multiple regression analysis, brachial-ankle pulse wave velocity significantly correlated with age and bone mineral density for both populations. Systolic blood pressure significantly correlated with brachial-ankle pulse wave velocity for the Ulaanbaatar group.
Despite significant lifestyle differences, similar relationships between atherosclerosis and osteoporosis were observed in women from Uku Island and Ulaanbaatar. Hypertension was a significant contributing factor for atherosclerosis for the Ulaanbaatar group.
血管钙化与骨质疏松之间的关联已有充分记录，但生活方式对动脉粥样硬化和骨质疏松的影响仍不明确。本研究评估了生活在日本乌库岛（以大米消费和捕鱼为生）和蒙古乌兰巴托（以肉类消费和游牧为生）的不同生活方式人群的动脉粥样硬化与骨质疏松之间的关系，并调查了生活方式对动脉粥样硬化和骨质疏松的影响差异。
参与者为50岁以上曾接受过动脉粥样硬化和骨质疏松医学检查的女性（乌库岛104人，乌兰巴托71人）。通过问卷调查获取生活习惯。使用定量超声测量右跟骨的骨密度。测量肱踝脉搏波速度作为动脉粥样硬化的指标。
两组之间的骨密度和肱踝脉搏波速度没有显著差异，尽管乌兰巴托的参与者在肉类和奶制品摄入量、不吃饭的次数以及子女数量方面均显著高于乌库岛的参与者。两组的肱踝脉搏波速度与年龄、收缩压和舒张压以及体重指数均呈显著正相关，与骨密度呈显著负相关。通过逐步多元回归分析，肱踝脉搏波速度与两个群体的年龄和骨密度均显著相关。乌兰巴托组的收缩压与肱踝脉搏波速度显著相关。
尽管生活方式存在显著差异，但在乌库岛和乌兰巴托的女性中观察到动脉粥样硬化与骨质疏松之间存在相似的关系。高血压是乌兰巴托组动脉粥样硬化的一个重要促成因素。
