Jaalkhorol Myadagmaa, Buckinx Fanny, Dashtseren Amarsaikhan, Baatar Seded, Khaidav Nansalmaa, Ochirdorj Gerelmaa, Darambazar Bolormaa, Batsaikhan Batmunkh, Munkhsonguuli Uugantamir, Lkhagvasuren Bayarmagnai, Byambaa Bulgantuya, Zhu Wu Qi, Avirmed Shiirevnyamba, Bruyere Olivier
Department of Health Research, Graduate School, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
Mongolian Naran Society for Osteoarthritis and Musculoskeletal Health, Ulaanbaatar, Mongolia.
Arch Osteoporos. 2025 May 6;20(1):58. doi: 10.1007/s11657-025-01548-x.
This study in Mongolia reveals that weaker grip strength and higher sarcopenia risk are linked to greater fracture risk and lower bone density. It highlights the crucial interplay between muscle and bone health, emphasizing the need for integrated musculoskeletal assessments to prevent fractures, especially in aging populations.
Research on the relationship between bone and muscle health in low- and middle-income countries, particularly Central Asia, remains limited.
To explore the correlation between muscle and bone health and to estimate the FRAX risk for major osteoporotic fractures (MOF) and hip fractures in the Mongolian population, stratified by age and sex.
A cross-sectional study was conducted in Ulaanbaatar and regional Mongolia from May to August 2024. Handgrip strength, sarcopenia risk (SARC-F) and bone mineral density using peripheral DXA (BMD T-score) were assessed. Fracture risks were estimated using the FRAX model.
Participants (n = 857; median age, 52 years; 53.0% women) had a median grip strength of 28 kg and a median BMD T-score of - 1.9. Most (69.5%) were at low sarcopenia risk (SARC-F < 4). SARC-F was moderately correlated with FRAX scores for MOF and hip fractures (r ≈ 0.27, p < 0.001) while grip strength was negatively correlated with FRAX scores(r = - 0.24, p < 0.001). Grip strength positively correlated with BMD T-scores (r = 0.22, p < 0.001). Fracture risks increased with age, with women showing higher rates than men. Higher sarcopenia risk (SARC-F ≥ 4) was associated with lower BMD and increased fracture risk. Lower grip strength (< 18 kg for women, < 28 kg for men) was linked to higher fracture risk and lower BMD.
This study highlights the interconnected nature of muscle and bone health in the Mongolian population, demonstrating that lower grip strength and higher sarcopenia risk are significantly associated with increased fracture risk and reduced bone density. These findings underscore the importance of integrated strategies for musculoskeletal health assessment and fracture prevention, particularly in aging populations.
这项在蒙古国开展的研究表明，握力较弱和肌肉减少症风险较高与骨折风险增加和骨密度降低有关。它突出了肌肉与骨骼健康之间的关键相互作用，强调了进行综合肌肉骨骼评估以预防骨折的必要性，尤其是在老年人群中。
在低收入和中等收入国家，特别是中亚地区，关于骨骼与肌肉健康关系的研究仍然有限。
探讨肌肉与骨骼健康之间的相关性，并按年龄和性别分层，估计蒙古人群中主要骨质疏松性骨折（MOF）和髋部骨折的FRAX风险。
2024年5月至8月在乌兰巴托和蒙古国其他地区进行了一项横断面研究。评估了握力、肌肉减少症风险（SARC - F）以及使用外周双能X线吸收法（BMD T值）测量的骨密度。使用FRAX模型估计骨折风险。
参与者（n = 857；中位年龄52岁；53.0%为女性）的中位握力为28千克，中位BMD T值为 - 1.9。大多数人（69.5%）肌肉减少症风险较低（SARC - F < 4）。SARC - F与MOF和髋部骨折的FRAX评分中度相关（r ≈ 0.27，p < 0.001），而握力与FRAX评分呈负相关（r = - 0.24，p < 0.001）。握力与BMD T值呈正相关（r = 0.22，p < 0.001）。骨折风险随年龄增加而升高，女性的发生率高于男性。较高的肌肉减少症风险（SARC - F≥4）与较低的骨密度和增加的骨折风险相关。较低的握力（女性<18千克，男性<2千克）与较高的骨折风险和较低的骨密度有关。
这项研究突出了蒙古人群中肌肉与骨骼健康的相互联系，表明较低的握力和较高的肌肉减少症风险与骨折风险增加和骨密度降低显著相关。这些发现强调了综合肌肉骨骼健康评估和骨折预防策略的重要性，尤其是在老年人群中。
