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良性前列腺增生与男性下尿路症状:家庭医生指南

Benign prostatic hyperplasia and male lower urinary symptoms: A guide for family physicians.

作者信息

Vasanwala Farhad Fakhrudin, Wong Michael Yuet Chen, Ho Henry Sun Sien, Foo Keong Tatt

机构信息

Department of Family Medicine, Sengkang Hospital at Alexandra Hospital, SingHealth, Singapore.

International Urology, Fertility and Gynaecology Centre, Mount Elizabeth Medical Centre, Singapore.

出版信息

Asian J Urol. 2017 Jul;4(3):181-184. doi: 10.1016/j.ajur.2017.05.003. Epub 2017 Jun 14.

DOI:10.1016/j.ajur.2017.05.003
PMID:29264228
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5717979/
Abstract

Male patients with lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) are increasingly seen by family physicians worldwide due to ageing demographics. A systematic way to stratify patients who can be managed in the community and those who need to be referred to the urologist is thus very useful. Good history taking, physical examination, targeted blood or urine tests, and knowing the red flags for referral are the mainstay of stratifying these patients. Case selection is always key in clinical practice and in the setting of the family physician. The best patient to manage is one above 40 years of age, symptomatic with nocturia, slower stream and sensation of incomplete voiding, has a normal prostate-specific antigen level, no palpable bladder, and no haematuria or pyuria on the labstix. The roles of α blockers, 5-α reductase inhibitors, and antibiotics in a primary care setting to manage this condition are also discussed.

摘要

由于人口老龄化,全球家庭医生接诊患有下尿路症状(LUTS)和良性前列腺增生(BPH)的男性患者越来越多。因此,采用一种系统的方法对可在社区管理的患者和需要转诊给泌尿科医生的患者进行分层非常有用。详细的病史采集、体格检查、针对性的血液或尿液检查以及了解转诊的警示信号是对这些患者进行分层的主要方法。病例选择在临床实践以及家庭医生的工作环境中始终是关键。最适合管理的患者是年龄在40岁以上,有夜尿、尿流缓慢和排尿不尽感等症状,前列腺特异性抗原水平正常,膀胱不可触及,并且尿试纸检查无血尿或脓尿的患者。本文还讨论了α受体阻滞剂、5-α还原酶抑制剂和抗生素在基层医疗环境中对这种疾病的管理作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e249/5717979/10923711a841/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e249/5717979/10923711a841/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e249/5717979/10923711a841/gr1.jpg

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Effects of hexanic extract of Serenoa repens (Permixon® 160 mg) on inflammation biomarkers in the treatment of lower urinary tract symptoms related to benign prostatic hyperplasia.锯叶棕果实提取物(保前列®160毫克)对与良性前列腺增生相关的下尿路症状治疗中炎症生物标志物的影响。
Prostate. 2015 Dec;75(16):1857-67. doi: 10.1002/pros.23059. Epub 2015 Aug 26.
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Diagnosis of prostate adenoma and the relationship between the site of prostate adenoma and bladder outlet obstruction.前列腺腺瘤的诊断及前列腺腺瘤部位与膀胱出口梗阻的关系。
Singapore Med J. 2013 Sep;54(9):482-6. doi: 10.11622/smedj.2013168.
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Urodynamic studies in adults: AUA/SUFU guideline.
Mixture of Corni Fructus and Schisandrae Fructus improves testosterone-induced benign prostatic hyperplasia through regulating 5α-reductase 2 and androgen receptor.
山茱萸与五味子混合物通过调节5α-还原酶2和雄激素受体改善睾酮诱导的良性前列腺增生。
Nutr Res Pract. 2023 Feb;17(1):32-47. doi: 10.4162/nrp.2023.17.1.32. Epub 2022 Jul 4.
4
Neferine improves oxidative stress and apoptosis in benign prostate hyperplasia via Nrf2-ARE pathway.小檗碱通过 Nrf2-ARE 通路改善良性前列腺增生中的氧化应激和细胞凋亡。
Redox Rep. 2021 Dec;26(1):1-9. doi: 10.1080/13510002.2021.1871814.
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Current consensus and controversies on male LUTS/BPH (part one).男性下尿路症状/良性前列腺增生的当前共识与争议(第一部分)
Asian J Urol. 2017 Jul;4(3):137. doi: 10.1016/j.ajur.2017.06.005. Epub 2017 Jun 15.
成人尿动力学研究:AUA/SUFU 指南。
J Urol. 2012 Dec;188(6 Suppl):2464-72. doi: 10.1016/j.juro.2012.09.081. Epub 2012 Oct 24.
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