小鼠红白血病细胞的发育程序。蛋白质合成抑制的影响。
Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis.
作者信息
Levenson R, Housman D
出版信息
J Cell Biol. 1979 Sep;82(3):715-25. doi: 10.1083/jcb.82.3.715.
Abstract
The relationship between protein synthesis and commitment to terminal erythroid differentiation by dimethylsulfoxide-treated murine erythroleukemia (MEL) cells has been studied. Treatment with cycloheximide blocks the commitment of MEL cells. The effects of cycloheximide are completely reversible, however. Treatment of MEL cells before commitment delays commitment for a period of time equal to the length of inhibitor treatment. Puromycin exerts a similar effect on the commitment of MEL cells. These results indicate that there is a continuous requirement for protein synthesis before the commitment event.
摘要
研究了二甲基亚砜处理的小鼠红白血病（MEL）细胞中蛋白质合成与终末红系分化的关系。用环己酰亚胺处理可阻断MEL细胞的分化。然而，环己酰亚胺的作用是完全可逆的。在MEL细胞分化之前进行处理会将分化延迟一段时间，这段时间等于抑制剂处理的时长。嘌呤霉素对MEL细胞的分化也有类似作用。这些结果表明，在分化事件发生之前，对蛋白质合成存在持续的需求。
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本文引用的文献
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PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINS.嘌呤霉素对蛋白质合成的抑制作用：嘌呤霉素掺入肽链的过程。
Proc Natl Acad Sci U S A. 1964 Apr;51(4):585-92. doi: 10.1073/pnas.51.4.585.
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The regulation of RNA synthesis and processing in the nucleolus during inhibition of protein synthesis.蛋白质合成抑制期间核仁中RNA合成与加工的调控
J Cell Biol. 1969 Apr;41(1):177-87. doi: 10.1083/jcb.41.1.177.
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The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes.环己酰亚胺及相关戊二酰亚胺类抗生素抑制网织红细胞核糖体上肽合成的机制。
J Biol Chem. 1971 Jan 10;246(1):174-81.
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Aberrant intranucleolar maturation of ribosomal precursors in the absence of protein synthesis.在缺乏蛋白质合成的情况下核糖体前体的异常核仁内成熟。
J Cell Biol. 1970 Jun;45(3):554-64. doi: 10.1083/jcb.45.3.554.
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Regulation of hemoglobin synthesis in a murine erythroblastic leukemic cell: the requirement for replication to induce hemoglobin synthesis.小鼠红白血病细胞中血红蛋白合成的调控：诱导血红蛋白合成对复制的需求。
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